Table 1a: Summary of Antibacterial Agents Flashcards Preview

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Flashcards in Table 1a: Summary of Antibacterial Agents Deck (61)
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1

What is the mechanism of action of penicllins?

cell wall synthesis inhibition (stage 3)

2

Are penicillins bacteriostatic or bactericidal?

bactericidal

3

Penicillin G and Penicillin V covers what spectrum of bacteria?

Gram + cocci (staph, strep, entero)
Gram - cocci (M. catarrhalis)
Gram + rods
Most anerobes (not Bacteriodes)

4

What drugs would you consider using on a penicillinase producing MSSA infection?

Penicillinase-resistant class (oxacillin, dicloxacillin, nafcillin)
Beta-lactamase inhibitors (Amox/clav, pip/tazo)

5

What are the extended spectrum penicillins?

Amoxicillin, ampicillin

6

Extended spectrum penicllins cover what bacteria?

Gram - rods (H. flu, E. coli, Proteus)
Gram + cocci (but not as well as Pen G/ Pen V)

7

What Penicillin covers pseudomonas?

Pip/tazo

8

How are most penicllins excreted?

Renal excretion

9

What are the adverse reactions to penicillins?

Anaphylaxis (rare)
Rash (common)
Convulsions at very high doses

10

What is the mechanism of action of cephalosporins?

Cell wall synthesis inhibition (stage 3)

11

Are cephalosporins bacteriostatic or bactericidal?

bactericidal

12

What are the 1st generation cephalosporins?

Cephalexin, cephradine, cefazolin

13

What are the 2nd generation cephalosporins?

Cefaclor, cefuroxime, cefoxitin

14

What are the 3rd generation cephalosporins?

Cefdinir, cefotaxime, ceftriaxone

15

What is a 4th generation cephalosporin?

Cefepime

16

1st generation cephalosporins cover what bacteria?

Gram + cocci, gram - rods
most anaerobes

17

2nd generation cephalosporins cover what bacteria?

Gram - rods (better than 1st gen coverage of gram - rods)
Most anaerobes

18

3rd generation cephalosporins cover what bacteria?

Gram - rods, moderate pseudomonas activity
most anaerobes

19

What gen of cephalosporins has good CNS penetration?

3rd generation

20

Which generation of cephalosporins has the best gram + cocci coverage

1st>2nd>3rd

21

Which generation of cephalosporins has the best gram - rod coverage?

3rd>2nd>1st

22

What cephalosporin covers for N. gonorrheoeae?

ceftriaxone

23

Which 3rd generation cephalosporin covers pseudomonas?

Ceftazidime

24

What is the mechanism of action of vancomycin?

Cell wall synthesis inhibition (stage 2)

25

Is vancomycin bacteriostatic or bactericidal?

bactericidal

26

Vancomycin covers what bacteria?

Narrow spectrum gram + cocci (MRSA, enterococci)
Anaerobes including C. diff

27

How are most cephalosporins excreted?

Renal excretion

28

How is vancomycin excreted?

Renal excretion

29

What is the mechanism of action for the carbapenems?

Cell wall synthesis inhibition (stage 3)

30

What type of bacteria would be appropriate to treat with carbapenems?

Multidrug resistant organisms