Paediatric biopharmaceutics Flashcards Preview

The Medicine (Y2) > Paediatric biopharmaceutics > Flashcards

Flashcards in Paediatric biopharmaceutics Deck (20):
1

What are the four factors that influence bioavailability?

Solubility
Dissolution
Permeability
First pass metabolism

2

In neonates there is an increase in acid secretion. True or false?

False - reduced acid secretion which may increase bioavail of acid labile drugs

3

What is meant by stomach capacity and how does this differ between children and adults?

The total volume the stomach can expand to and this is much less in neonates than in adults

4

Saliva flow rate in children is much less than in adults. True or false?

True

5

Irregular intestinal motility in paediatric patients leads to very variable transit times. True or false?

True

6

In the colon, transit time in a neonate is between 2-48 hours. True or false?

False - 28-96 hours

7

GIT is the same length from birth till growth is complete. True or false?

False - increases in length and diameter

8

Children generally have a smaller liver size and hepatic blood flow per body weight than adults. True or false?

False - have a larger liver size and hepatic blood flow

9

Relative bioavailability studies are carried out on children. True or false?

False - unethical as it involves a lot of blood sampling

10

What is PBPK and what is its use in paediatric formulation bridging?

Physiologically based pharmacokinetic modelling - key tool to help predict likely formulation performance

11

How does PBPK work?

Mechanistically stimulates the processes involved in absorption and PK performance.

12

What is the age range for a neonate?

0-27 days

13

How old is an infant?

1-23 months

14

How old is a child?

2-11 years

15

What is the age range for an adolescent?

12-18 years

16

What is the age range for an adult?

> 18 years

17

Is the pH of the stomach in neonates more acidic or basic than adults?

More basic

18

Th pH in the SI for a child and adult is roughly the same. True or false?

True

19

Which drugs are better absorbed in GIT of neonates?

Basic drugs have decreased solubility and acidic drugs have increased solubility

20

The stomach capacity in a neonate can be as little as __ ml

10