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Flashcards in API and dissolution Deck (7):
1

By increasing surface area, dissolution is reduced. True or false?

False - increasing surface area increases dissolution

2

What factors affect dissolution (Noyes-Whitney equation)?

Surface area
Diffusion coefficient
Thickness of diffusion layer
Saturation conc in diffusion layer
Concentration in GI fluid

3

Lubricants increase dissolution rates. True or false?

False

4

What are the 3 equipments that are approved by the BP and EP for intrinsic dissolution rate measurements?

Basket
Paddle
Flow through cell

5

Paddle apparatus has a faster rotation rate than basket. True or false?

False - slower

6

What are the experimental conditions for IDR measurements, as stated in BP?

Pre-formulation is determined in 0.1M HCl, 0.1M NaOH and water
UV-spec is the analytical method of choice
Solubility is measured at fridge temp (4), room temp (25) and body temp (37)

7

Which equation governs dissolution?

Noyes-Whitney equation