Flashcards in API and dissolution Deck (7):
By increasing surface area, dissolution is reduced. True or false?
False - increasing surface area increases dissolution
What factors affect dissolution (Noyes-Whitney equation)?
Thickness of diffusion layer
Saturation conc in diffusion layer
Concentration in GI fluid
Lubricants increase dissolution rates. True or false?
What are the 3 equipments that are approved by the BP and EP for intrinsic dissolution rate measurements?
Flow through cell
Paddle apparatus has a faster rotation rate than basket. True or false?
False - slower
What are the experimental conditions for IDR measurements, as stated in BP?
Pre-formulation is determined in 0.1M HCl, 0.1M NaOH and water
UV-spec is the analytical method of choice
Solubility is measured at fridge temp (4), room temp (25) and body temp (37)