Pain and Anxiety Week 3 Flashcards
(146 cards)
What is the mechanism of action for topical anesthetics?
- Blocks nerve conduction at mucous membrane surfaces
- Decreases Na+ permeability = decreases depolarization = blocks nerve impulse
(MOA is similar to injectable LAs)
What are the different forms of topical anesthetics?
Gel
Ointment
Metered and unmetered sprays
Cream
Liquid
Lozenges
What is the range of effective concentrations for topical anesthetics? What does this depend on?
0.2% - 20%, depends on form
What is the choice of method of delivery for topical anesthetic based on?
Each individual patient
Which topical anesthetic is associated with methemoglobinemia?
Benzocaine sprays
(recall that injectable procaine has the same issue)
Why do we need the site to be dried with gauze or sponge before we apply the topical anesthetic?
dryer site = will absorb the anesthetic better
(won’t get washed away by saliva)
How long should topical anesthetic be placed at site?
1-2 mins
What is the tissue depth of topical anesthetic?
2-3 mm
What are 3 common topical anesthetics used in dentistry?
Benzocaine
Lidocaine
Combination of Benzocaine + Butamben + Tetracaine = Cetacaine
Is Benzocaine (topical) an ester or amide?
Ester
Which topical has a very low toxicity due to the fact that it has SLOW absorption?
Benzocaine
What is the onset of Benzocaine (topical)?
30 seconds - 2 mins
What is the duration of Benzocaine (topical)?
5-15 mins
Which topical has a 20% concentration?
Benzocaine
Where is Benzocaine (topical) metabolized?
Plasma + some liver
What is the MRD of Benzocaine (topical)?
None
What is the pregnancy category for Benzocaine (topical)?
pregnancy = category C; lactation unknown safety
What is Benzocaine (topical) spray associated with?
Methemoglobinemia
Which topical has a very low toxicity due to the fact that it has POOR absorption?
Lidocaine
Which topical is good for those with an ester allergy?
Lidocaine
Is Lidocaine (topical) an ester or amide?
Amide
What is the onset of Lidocaine (topical)
2-10 mins
What is the duration of Lidocaine (topical)
15-45 mins
Which topical has a concentration of 2%-5%?
Lidocaine