Past papers Flashcards
(108 cards)
1
Q
The MHC Ag are
A
Plasma membrane glycoproteins
2
Q
Extravasation of lymphocytes is helped by
A
Diverse adhesive proteins
3
Q
They are professional phagocytes, except
MPH
Neutrophils
Basophils
Monocytes
A
Basophils
4
Q
Ig-a chain is found on heavy chain of Ig__
A
IgA
5
Q
Complement genes in the MHC III region
A
C2
C4
B
6
Q
Myeloperoxidase is most commonly epressed on
A
Neutrophil granulocytes
7
Q
____ have an essential role in processing of endogenous Ag
A
Proteasomes
8
Q
__ is involved in mast cell and basophil degranulation
A
C3a
9
Q
Progenito cell for monocytes
A
Myeloid cells
10
Q
PRR do not identify
A
Unmethylated sequences
11
Q
CD Ag are
A
Differentiation Ag
12
Q
Homing receptors are present on the surface of
A
Lymphocytes
13
Q
TNF-a is located on gene ___
A
MHC III
14
Q
CD4 chain binds to _____ of MHC2
A
Constant chain
15
Q
Cells having IL6 receptors before inflammation
A
Liver cells
16
Q
Defensins in structure are
A
Cyclic peptides
17
Q
Conc. of Albumin in acute phase reaction
A
Decreased
18
Q
High affinity Fc epsilone receptor are found on
A
Basophil granulocytes and mast cells
19
Q
Size of TCR repertoire is
A
Super big
More then a billion
20
Q
Both Ig and TCR are characterized by
A
Domain like globular structure
21
Q
Number of hypervariable regions in Ig and TCR is
A
3
22
Q
Secondary innume response has
A
Shorter latency and higher amplitude
23
Q
Adhesive proteins play a part in
A
Majority of cell to cell interactions
24
Q
Chemotactic substance of bacterial origin
A
LPS
25
IC bacterias are mediated mostly by
Activated MPH
26
Autoimmune disease are enhanced by
Estrogen
27
Which of TCR chains are hypervariable
a, b, gamma, delta
28
A receptor that doesnt play a role in endocytosis or phagocytosis
TCR
29
PAMP-PRR intercation induce
IL1
IL8
TNF a
30
When do naive T cells enter the lymph nodes?
Anytime, through the HEV
31
RAG enzymes are present in
Bone marrow
32
Who has c-kit on its surface
Pluripotent HSC
33
Main biological function of IL2 on T cells
GF
34
Major costimulatory factor on APC
B7
35
Inheritance of MHC alleles is
Codominant
36
Major costimulatory factor on T cell
CD28
37
Cytokines are not
Ag specific
38
IL which inhibits cellular immune response
IL4
39
___ is most likely to promote acute Neut. inflammatory response
Th17
40
IL6 role in B cell maturation
Terminal differentiation of B cell matures to plasma cells
41
Class switch in B cell activation is regulated by
Helper T cell cytokines
42
Th1-like cytokines are produced by
NK cells
43
Onvariant gamma chain has its role in
Processing of exogenous Ag
44
IFN of Th1
IFN gamma
45
Most important role of IL2
Induces B cell differentiation
46
Number of thymocytes during maturation
| Increase/Decrease
Decrease
47
Mutual inhibition is by
UFN-gamma and IL4
48
Affinity maturation happens in
Periphery
49
CD__ has IgE binding capacity
CD23
50
Type of cells produced in Bone marrow
Every myeloid and lymphoid cell types
51
CXC chemokines are produced by
Lymphocytes
52
Changes during isotype switch
Constant regions of heavy chain
53
The Ag binding part of a Bcell determines his
Idiotype
54
IL23 induces
Th17
55
Mononuclear phagocytosis includes which cell
Kupffer cell
56
Where can we find double negative T cells?
Subcapsular area of the thymus
57
Which mediator can lead to systemic inflammation
IFN-a
IFN-gamma
TNF-a
TNF-a
58
Hybridomas are made from combining
B cell and myeloma cell
59
Which process cannot be activated by complement system?
Ab production
60
Light chain of BCR
Lambda
61
Light chain of Ab is made of
V
J
1 or 2 possible different constant region
62
Marker of T cell activation
IL2-R
63
Intgein structure
Heterodimers
64
Do NK cells express FC epsilon receptor?
No
65
WHich cell produces many IFN-gamma?
Th1
66
Start and end point of TAP
Golgi-cytoplasm
67
CD1 presents
LIpids
68
Negative acute phase proteins
Albumin
Transferrin
Antithrombin
69
Which R cannot be an opsonizing R?
FcR
CR
Lectin R
PRR
PRR
70
Which psychiatric disease preasents with symptoms symilar to those seen inInflammation and immune activation?
Depression
71
CD34=
HSC progenitor marker
72
Main co-stimulatory in B cell activation
CD40-CD40L
73
Paracortical region of lymph nodes contains ,ainly
T cells
74
Alternative pathway activation can be measured by
Erythrolysis
75
Edema in HAE is due to
Bradikinin
76
M spike is common in which disease
Multiple myeloma
77
Which of these cells have no signaling function in inflammation?
B lymphocytes
Keratinocytes
MPH
Fibroblasts
B lymphocytes
78
Natural Ab are:
Low affinity, cross-reacting autoAb
79
Receptor for HIV is
CD4
80
___ denatures proteins during Western-blot
SDS
81
Which one is a chemoattractant for "homing"
IL8
IL1
IL6
IL1
82
Where do B cells go through somatic hypermutation
Periphery
83
Which cytokine is responsible for class switching to IgA?
TGF-beta
beta is ending with a
84
__ and _____ secrete IL4
Th2
| Mast cells
85
```
Which makes covalent bond in complement activation? C1
C2
Crq
C4
C5
```
Crq
86
Invarians chain action
Inhibition of MHC II
87
HSN II is medited by which Ab
IgG
88
CD23=
Receptor for IgE
89
Immunological homunculus=
Obligate reaction of the immune system to dominant Ag
90
Which cytokines promotes angiogenesis around the tumor?
TGF-beta
אנגגגיוגגגנסיס
91
Decrease MHC expression can cause
Tumor escape
92
Defensins are
Peptides
93
Which cells dominate in the follicles of lymph nodes?
B cells
94
FSC=
Forward Scatter
95
FSC measures
cell size
96
SCC=
Side Scatter
97
SCC measures
Internak complexability
98
Cross presentation occurs when ___ cells present ___ Ag on MHC1 molecules to elict ___ T cell response against viral tumor Ag
Cross presentation occurs when APC cells present exogenous Ag on MHC1 molecules to elict CD8+ T cell response against viral tumor Ag
99
Which lympholid cells do not express Ag binding receptors
NK
100
Is the liver a hematopoietic organ?
Only in the embryo
101
Ig super family membares (give 5)
```
MHC1, MHC2
CD4
CD8
CD28
TCR
BCR
```
102
CD28 is expressed on
T cells
| co-stimulation with B7
103
Against which pathogenes does the complement system protect?
Bacteria
Fungi
Protozoa
104
Steps of inflammatory extravasation (5)
```
Attachment
Rolling
Activation
Adhesion
Migration
```
105
Handaling of exogenous Ag before presenting them on the MHC2 is done where?
Endosome/Lysosome
106
Serum sickness is type __ HSN
III
107
Serum sickness causative agent
Mediacation (Penicillin)
| Passive immunization
108
SLE causative agent
Genetic
| Enviormental
