Week 3 Lecture

Question 1

First complement component is

Answer 1

C1

Question 2

Complement activation has __ pathways:

Answer 2

3
Classical
Lectin
Alternative

Question 3

c3b cleaves (2)

Answer 3

c3 (positive feedback)

c5

Question 4

The classical complement pathway is initiated by __________________ with the antibody isotypes ___ , ___

Answer 4

antigen-antibody complexes

IgG and IgM

Question 5

What are the components of classical C3 convertase?

Answer 5

C4bC2b

Question 6

Which enzyme cleaves C3?

Answer 6

C4bC2b (C3 convertase)

Question 7

What are the components of C5 convertase?

Answer 7

C4bC2bC3b

Question 8

What are the components of the membrane attack complex?

Answer 8

Poly C9

C5b678

Question 9

What binds the Ag Ab complex in the Classical pathway?

Answer 9

C1qrs

Question 10

Lectin pathway has the ability to bind ____

Answer 10

Sugar

Question 11

In contrast to the classical complement pathway, the lectin pathway does not __________________

Answer 11

recognize an Ab-Ag

Question 12

The lectin pathway starts with __________________

Answer 12

Mannose-Binding Lectin or Ficolin

Question 13

Multimers of MBL form a complex with _____

Answer 13

MASP-1 or MASP-2

Mannose-binding lectin-Associated Serine Protease

Question 14

MASPs are very similar to _________ molecules of the classical complement pathway

Answer 14

C1r and C1s

Question 15

When the carbohydrate-recognising heads of MBL bind to specifically arranged mannose residues on the surface of a pathogen, MASP-1 and MASP-2 are activated to cleave complement components ________

Answer 15

C4 and C2

Question 16

The Alternative pathway is triggered when __________________________

Answer 16

the C3b protein directly binds a microbe

Question 17

What is the job of factor D in the Alternative pathway?

Answer 17

factor D cleaves C3b+B into C3b+Bb

Question 18

What is the regulator of complement activation that stabilizes the alternative pathway convertases

Answer 18

Properdin

Question 19

What is the C5 convertase in case of the Alternative pathway?

Answer 19

C3bBbC3b

Question 20

What innitiates the Alternative pathway?

Answer 20

Spontaneous hydrolysis of C3

Question 21

_____ _____ are Anaphylatoxins

Answer 21

C3a

C5a

Question 22

The membrane-attack complex (MAC) forms_______ .

Answer 22

transmembrane channels

Question 23

Other name for CR2

Answer 23

CD21

Question 24

CR2 binds

Answer 24

C3dg- opsonized Ag

Question 25

CR3, CR4 binds

Answer 25

iC3b | Participate in Phagocytosis

Question 26

What is the inhibitor of the classical pathway?

Answer 26

C1INA (Plasma protein)

Question 27

What are the inhibitors of the C3 convertase?

Answer 27

I factor (in the plasma) DAF (Decay Accelerating factor) MCP (Membrane Co-factor Protein)

Question 28

How can we inactivate Anaphylatoxins?

Answer 28

cleavage of C3a ans C5a By Serum Carboxypeptidase

Question 29

How can we inhibit the MAC?

Answer 29

Protectin (CD59) - Lymphocyte surface molecule

Question 30

What is the most frequent withborn complement deficiency?

Answer 30

C2

Question 31

C1 Inh deficiency leads to

Answer 31

Hereditary angioneurotic edema (HANO,HAE)

Question 32

Hereditary angioneurotic edema (HANO,HAE) is due to

Answer 32

C1 Inh deficiency

Question 33

What is the effect of C1 in immune regulation?

Answer 33

In the absence of C1 Inh, spontaneous classical activation of C4 and C2 cleavage

Question 34

What other systems are affected by C1 Inh?

Answer 34

In its absence, there is increased bradykinin synthesis

Question 35

C1 is made of

Answer 35

DImerX3 with C1r and C1s

Question 36

C1 cleaves

Answer 36

C4 and C2

Question 37

Membrane attack coplex=

Answer 37

C5b678+Poly C9

Question 38

In the alternative pathway, C3b binds

Answer 38

Factor B

Question 39

C3bB is cleaves by ____ to produce ____

Answer 39

Factor D | C3bBb+Properdin

Question 40

C3bBb cleaves ___ to produce ____

Answer 40

C3 | C3bBbC3b

Question 41

Which C3 binds complement receptors and enhance phagocytosis?

Answer 41

C3b C3bi C3dg

Question 42

Which receptor on RBC recognize C3b+Ag+Ab?

Answer 42

CR1

Question 43

CR2 is located on

Answer 43

B cells

Question 44

CR2 recognize ___

Answer 44

C3dg

Question 45

CR2 - C3dg participate in

Answer 45

B cell activation

Question 46

CR3, CR4 integrin receptors bind ___ and participate in ____

Answer 46

iC3b | Phagocytosis

Question 47

Inhibition of classical pathway

Answer 47

C1 inhibitor

Question 48

C3 convertase inhibition

Answer 48

I factor DAF MCP

Question 49

Inactivation of Anaphylatoxins by

Answer 49

SCPN Serum Carboxy-Peptidase N cleave C3a and C5a

Question 50

Inhibition of MAC by

Answer 50

Protectin

Question 51

Other name for protectin

Answer 51

CD59

Question 52

MASP

Answer 52

Mannosie Assosiated Serine Protease

Question 53

Mot common withborn complement deficiency?

Answer 53

C2

Question 54

Early complement deficiency leads to

Answer 54

Autoimmune disease

Question 55

Late complement deficiency leads to

Answer 55

Pyogenes and Neisseria infections

Question 56

C1 inh. deficiency leads to

Answer 56

Hereditary Angioneuretic Edema

Question 57

What happens in the absence of C1 inhibitor?

Answer 57

Spontaneous classical activation and C4 / C2 cleavage

Question 58

Location of C3 convertase genes

Answer 58

MHC III in HLA region

Question 59

Positive gene expression of acute plasma proteins examples

Answer 59

``` B factor C3 Fibrinogen C1 inhibitor CRP SAA (Serum Amyloid A) ```

Question 60

Negative gene expression of acute plasma proteins examples

Answer 60

Transferrin Abumin Fibronectin

Question 61

Biological functions of acute phase proteins

Answer 61

Silencing Infllammatory signals Reducing inflammation Homeostasis