Practice Q

Question 1

How many AA can MHC I present

Answer 1

8-9

Question 2

How many AA can MHC II present

Answer 2

15-25

Question 3

B2-microglobulin is present on chromosome __

Answer 3

15

Question 4

Haplotype=

Answer 4

Combination of alleles at adjacent locations on chromosome that are transmitted togather

Question 5

Locus of HLA is detemined as

Answer 5

Capital letter

HLA-A

Question 6

Allele of HLA is determined by

Answer 6

Number

HLA-A7

Question 7

Which HLA is the most important to check in case of kidney transplantation?

Answer 7

HLA-DR

Question 8

Most important autoAb in autoimmune disorders (5)

Answer 8

ANA
ANCA
Anti=phospholipid Ab
RF
ACPA

Question 9

RF means

Answer 9

Rheumatoid Factor

Question 10

ANA binds

Answer 10

Contents of the cell nucleus

Question 11

ANA means

Answer 11

Anti Nuclear Ab

Question 12

RF mechanism

Answer 12

RF is an Ab against the Fc fragments of IgG

Question 13

ANCA means

Answer 13

Anti Neutrophil Cytoplasmic Ab

Question 14

Reaction in Type II HSN

Answer 14

Cell or matrix associated Ag connectig IgG

Question 15

Which HSN are mediated by IgG?

Answer 15

II

III

Question 16

Myasthania Gravis is type __ HSN

Answer 16

II

Question 17

Myasthania Gravis mechanism

Answer 17

Ab against Ach receptors

Question 18

Basedow disease mechanism

Answer 18

Stimulatory Ab against TSH-R

Question 19

Direct Coombs test=

Answer 19

Detects Ab on cell surface

Question 20

Indirect Coombs test=

Answer 20

Detects free Ab

Question 21

Describe indirect coombs test

Answer 21

We take mather serum with the Rh+ Ab
We add baby Rh+ RBC
Mothers Ab attach to RBC Rh+ Ag
We add anti-human Ab
Agglutination

Question 22

Ag in case of Celiac disease

Answer 22

Gliadin (grain protein)

Question 23

Type IV HSN happens after __

Answer 23

2-3 days

Question 24

Effects of Histamine on H1-R

Answer 24

Increased mucosa secretion
Increased vascular permaebility
Airway constraction

Question 25

Effects of Histamine on H2-R

Answer 25

Vasodilation | Airway mucus secretion

Question 26

Effects of Histamine on H4-R

Answer 26

Itch | Inflammatory cells recruitment

Question 27

What else is released from mast cells?

Answer 27

Prostaglandins Proteases Heparin

Question 28

Which cells release Histamine?

Answer 28

Mast cells | Basophils

Question 29

Anaphylactic=

Answer 29

IgE mediated

Question 30

Anaphylactoid=

Answer 30

Direct mast cell secretion

Question 31

Anaphylactoid can happen when

Answer 31

Eating high Histmine containing foods like red wine

Question 32

Mechanism of HAE

Answer 32

C1 inhibitor deficiency

Question 33

HAE mediator

Answer 33

Braykinin

Question 34

Which enzzyme will we detect in serum in case of allergy and why?

Answer 34

Tryptase | Bcs. it is released of Mast cells along Histamine