Week 4 lecture Flashcards
(26 cards)
Exogenous Ag are presented by
MHC II
Endogenous Ag are presented by
MHC I
MHC gene is on chromosome
6
Short arm
(MHCix. c sounds like si-six)
Antigen binding domain of MHC I is composed of
α1 and α2 domains
Antigen binding domain of MHC II is composed of
α1 and β1 domains
MHC I is present where?
All nucleated cells
MHC II is present where?
DC
B cell
MPH
MHC I has a ____ pocket and MHC II has an ____ pocket
close/open
MHC I has a closed pocket and MHC II has an open pocket
Low expression of MHC on which cells?
Fibroblasts
Muscle cells
Liver cells
How does the degraded endogenous proteins get to to the ER?
Through TAP1/TAP2
TAP meaning
Transporters Associated with Ag Processing
Which system trims peptides in the lumen of the ER?
ERAP
Aminopeptidase associated eith Ag processing in the ER
What transforms constitutive proteasome to immunoproteasome
IFN gamma
The genetic code of the TAP proteins is located within the _____ region
MHC II
What can happen in TAP deficiency?
Necrotizing Granulomatous
Cathepsin B is activated by ____
Low pH
What catalyze the removal of CLIP?
HLA-DM and HLA-DO
CLIP is a part of the __________
Invariant chain
Invariat chain is present in ____
MHC II
What presents lipid Ag?
CD1
What is needed in oeder to activate naive T cells?
MHC-peptide complex
Costimulation
Activated Th cells produce ___
IL2
Where does cross-presentation happens?
CD8+ DC’s only
How many different types of MHC can an APC cells express?
12
