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S.N Immunology I > Week 13- Transplantation > Flashcards

Week 13- Transplantation Flashcards

(45 cards)

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1
Q

Graft=

A

Transplanted cells, tissue or organ

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2
Q

Ortotopic transplantation=

A

Graft is placed to the original anatomic location

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3
Q

Heterotropic transplantation=

A

Graft is placed to the different anatomic location

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4
Q

Autotransplantation=

A

Donor and recipient are the same person

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5
Q

Most transplanted orans (4)

A

Kidney
Liver
Heart
Lung

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6
Q

Most frequent transplantation is

A

Transfusion

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7
Q

Allograft=

A

Different person is the Donor

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8
Q

Isograft/Sygraft=

A

Monozygotic twins

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9
Q

Autograft=

A

Donor and recipient are the same person

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10
Q

Xenograft=

A

Donor is an animal

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11
Q

Which MHC gene must be same for donor and patient

A

HLA-A
HLA-B
HLA-DR

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12
Q

Significance of matching blood types

A

Blood group Ag are also present on blood vessel endothelial cells as part of the donor tissue

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13
Q

No cytoablation is seen in ______ transplantation

A

Organ

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14
Q

____ therapy is needed in case of Organ transplantation

A

Suppressive

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15
Q

HLA matching is critical in case of ____ transplantation

A

Bone marrow

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16
Q

______ is necessary in case of bone marrow transplantation

A

Cytoablation

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17
Q

Major complication in case of bone marrow transplantation

A

GVHD

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18
Q

Major complication in case of organ transplantation

A

Rejection

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19
Q

Allograft=

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A

Different person is the Donor

20
Q

Host vs Graft reaction in case of

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A

Transplantion of Non-immunocometent tissues

21
Q

non-immunocometent tissues examples (3)

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A

Kidney
Liver
Skin

22
Q

Graft vs Host reaction in case of

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A

Transplantion of Immunocometent tissues

23
Q

Immunocometent tissues examples

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A

HSC
Thymus
Spleen
But also- Lung, Liver, Gut

24
Q

HVG means

25
GVH means
Defenceless recipient The donor cells attack the cells left of the donor. Can be a good thing!!! if the patients own cells are bad
26
1 year survival of liver transplantation
>75%
27
Heart transplantation carried out if the expected one year survival is
Less than 50%
28
5 years survival of heart transplantation
80%
29
5 years survival of liver transplantation
70%
30
1 year survival of pancreas transplantation
72%
31
Langerhans island transplantation
Islets established in liver sinusoids
32
Cornea transplantation
60-70% acceptance
33
Direct recognition role in rejection
Acute rejection
34
Indirect recognition role in rejection
Chronic rejection
35
Extent of rejection in Direct recognition
Intense
36
Extent of rejection in Inirect recognition
MildIndirect recognition
37
Direct recognition=
Recognition of allogenic MHC/peptide complex on the surface of donor APC within the graft
38
Indirect recognition=
Recognition of allogenic donor MHC molecule derived peptdie epitope by recipient (patients) APC's
39
Which Ag play a role in hyperacute rejection? (3)
ABO blood Ag VEC (vascular endot. cell) Ag HLA Ag
40
Origin of HLA sensitization
Transfusion Pregnancy ...
41
Acute rejection happens ___ after transplantation
Weeks to months (mostly 1 month after)
42
Significans of chronic rejection
Fibrosis
43
Mechanism of chronic rejection
CD4+ T cells | MPH
44
How can we prevent transplantation rejection?
``` Steroid infusion Anti-CD28 Anti-MHC2 Anti-CD4 Immunosuppression Donor selection ```
45
Acute GVHR is life threatening in case of
Endothelial cell death in GI tract which can lead to GI tract bleeding

S.N Immunology I (16 decks)

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