Week 11

Question 1

NALT meaning

Answer 1

Nasopharynx Assosiated Lymph Tissue

Question 2

Mucosa immunity includes

Answer 2

MALT
NALT
GALT

Question 3

How many of all lymphocytes founs in the mucosa?

Answer 3

3/4

Question 4

Payers patch: what can we find in the SED

Answer 4

(Sub Epithelial Dome)

Dendritic Cells

Question 5

Payers patch: what can we find in the TDA

Answer 5

(T Dependent Area)

T cells around follicles of B cells

Question 6

M cells function

Answer 6

Above Payer patches

Contineous Ag uptake

Question 7

M cells take up Ag by

Answer 7

Endocytosis

Phagocytosis

Question 8

How else can DC capture Ag frok the lumen?

Answer 8

Extend processes across the epithelial layer to capture Ag from guts lumen

Question 9

What is the ligand for CCR9?

Answer 9

CCL25

Question 10

MACDAM binds

Answer 10

a4b7 integrin

Question 11

Two compartments of the mucosal immune system

Answer 11

Epithelium

Lamina propria

Question 12

Which T cell is present on the Lamina propria?

Answer 12

CD4

Question 13

Which T cell is present on the Epithelium?

Answer 13

CD8

Question 14

Intra Epithelial Lymphocytes

Answer 14

CD8 T cells
50% gamma-delta-T
Many NK cells

Question 15

IgA appears as ____ in the blood

Answer 15

Monomer

Question 16

IgA appears as ____ on the mucosa

Answer 16

Dimer

Question 17

Which cytokines will induce the formation of IgA producing cells

Answer 17

IL2
IL5
TGF b

Question 18

TLR location in the gut?

Answer 18

Balolateral surface (Dimeric TLR)
IC (Monomeric NLR)
DC (Low levels of TLR)

Question 19

Endosome have TLR number

Answer 19

TLR-9

Question 20

Balolateral surface have TLR number

Answer 20

TLR-5

Question 21

NLR action

Answer 21

Caspase-1

Activation of IL-1

Question 22

CD11b + DC activates

Answer 22

Th17

Question 23

CD103 + DC activates

Answer 23

Treg

Question 24

Naturally present bacteria in the dental plaque

Answer 24

Fusobacterium nucleatum

Question 25

Bacteria present in periodontitis

Answer 25

Porphyromonas gingivalis

Question 26

Fusobacterium nucleatum promotes ______ expression

Answer 26

B Defensin | Fusobacterium nucleatum is resistant agains B defensin but Porphyromonas gingivalis NOT!

Question 27

Where else can we find Porphyromonas gingivalis in case of periodontitis?

Answer 27

Atheromatous plaque