Week 1+2 Q

Question 1

What do T cells recognize?

Answer 1

Linear peptide sequence in the groove of the MHC

Question 2

Primary immune response characteristics

Answer 2

Slow
Low A
IgM אני מגיע ראשון

Question 3

Secondary immune response characteristics

Answer 3

Fast
High A
IgG

Question 4

Natural immunity also clled

Answer 4

Innate

Question 5

Molecule systems of Innate immunity

Answer 5

Soluble antimicrobial molecules
Natural Ab
Complement system

Question 6

Defensins act as

Answer 6

Direct cytotoxicity

Question 7

Defensins are expressed in

Answer 7

Salivary glands
Paneth cells
Leukocytes

Question 8

Most Defensins are _____ molecules

Answer 8

Amphipatic

Question 9

Job o Defensins

Answer 9

Attach the membrane
Bend the membrane
Create pore
Internal content release

Question 10

Where can we find alpha-Defensins?

Answer 10

Neut.
Inflammation site
Salivary duct cells

Question 11

Where can we find Beta-Defensins?

Answer 11

Epithelia

Salivary duct

Question 12

How do Lysozyme destroy bacterial cell wall?

Answer 12

Breaking glycosidil bonds btw. peptydoglycan components

Question 13

What can cause deprivation of bcterial nutrients?

Answer 13

Calprotectin

Question 14

Recruited MPH activation types

Answer 14

M1

M2

Question 15

M1=

Answer 15

Classically activated

Inflammatory cytokines

Question 16

M2=

Answer 16

Alternatively activated

Suppression host defence

Question 17

What are the three modes of intracellular killling

Answer 17

1. Lysosomal antibacterial substance
2. O2 dependent respiratory burst
3. NO mediated

Question 18

CGD means

Answer 18

Chronic Granulomatous Disease

Question 19

CGD happens bcs.

Answer 19

Lack of oxidase in phagocytes

Causes recurrent infections

Question 20

NK cell is a type __ which produce ____

Answer 20

1

IFN-gamma

Question 21

NK kill ____ and ____

Answer 21

Virus infected cells

Tumor cells

Question 22

Dual receptor system of NK consist of

Answer 22

Killer Inhibitory Receptor (KIR)

Killer Activating Receptor (KAR)

Question 23

KAR binds

Answer 23

Ubiquitous molecule

Question 24

KIR binds

Answer 24

MHC 1

Question 25

WHen will NK cell kill something?

Answer 25

When KAR binds Ubiquitous molecule BUT KIR is free (Bcs. no MHC 1 !! - not own body cell)

Question 26

Example for KIR

Answer 26

NKG2A

Question 27

Example for KAR

Answer 27

NKG2D

Question 28

ADCC means

Answer 28

Ab Dependent Cellular Cytotoxicity

Question 29

What happens in ADCC

Answer 29

Effector cell of immune system lyses a target cell, whose memb. surface Ag have been bound by specific Ab

Question 30

Which molecule on NK cells is involved in ADCC?

Answer 30

CD16

Question 31

Phagocytes Receptors

Answer 31

1. Opsonic -R | 2. PRR

Question 32

Example for Opsonic -R

Answer 32

Fc-R | Complement-R

Question 33

Fc-gamma binds

Answer 33

IgG like daaa g-G

Question 34

Where can we find CD14

Answer 34

Mostly MPH

Question 35

CD14 job

Answer 35

Binds bacterial LPS (PAMP)

Question 36

Membrane PRR examples

Answer 36

``` Scavenger Lectin COmplement NK cell TLR ```

Question 37

Which TLR recognize LPS?

Answer 37

TLR4

Question 38

TLR function as monomer T/F

Answer 38

False. They function as Dimer

Question 39

Nucleic acids are recognized by TLR in ______

Answer 39

Endosomes

Question 40

Which receptors recognize intracellular bacterias?

Answer 40

NLR (Nod Like R)

Question 41

Which receptors recognize virus?

Answer 41

RLR (RIg Like R)

Question 42

Ligand binding to TLR activates the transcription of ___

Answer 42

NF-kB

Question 43

Which receptor on MPH is a LPS-R?

Answer 43

CD14

Question 44

NF-kB will control the transcription of

Answer 44

IL-1 betta | IL-18

Question 45

Necrotic ceall death will release ___

Answer 45

DAMP (Damage Assosiated Molecular Pattern)

Question 46

What are DAMP's?

Answer 46

Molecules release upon necrosis | Trigger generation of EC pro inflammatory molecules

Question 47

Inflammasome is made of

Answer 47

NLR ASC Caspase 1