Week 8

Question 1

Which TLR recognizes LPS?

Answer 1

TLR4

Question 2

Which cells can make DNA traps?

Answer 2

Neutrophils

Eosinophils

Question 3

What will we see i blood serum in case of bacterial infection

Answer 3

Neutrophils

Question 4

Bacterial infection increases _____ levels

Answer 4

Procalcitonin

Question 5

We will see increase in procalcitonin levels especially in

Answer 5

Systemic infection

Question 6

Innate immunity to IC bacterias

Answer 6

Bacterias are resistant to phagocytosis (Bcs they are inside cells!)

Question 7

Activation of NK by IL__

Answer 7

IL12

Question 8

Adaptive immunity to IC bacterias

Answer 8

Th1 (IFN-gamma activates MPH)

CD8 kill infected cells

Question 9

Granulomas contain

Answer 9

Th1 
MPH
Caseous center
...
...

Question 10

How IC bacterias escape immunity?

Answer 10

• Phagolysosome inhibition

- Hemolysin production (MPH inhibition)

Question 11

IC bacteria infection.

What will we see in the blood?

Answer 11

Lymphocytosis

Monocytosis

Question 12

Which parasites can we see in the GI?

Answer 12

Helminths

Question 13

Innate immunity to parasites? (4)

Answer 13

Recognition by PRR
Resistant to complement system
MPH
Eosinophils

Question 14

Which cytotoxic cationic proteins does Eosinophils secretes?

Answer 14

E. Peroxidase
E. Cationic Proteins
E. Neurotoxins

Question 15

Adaptive immunity to parasites? (2)

Answer 15

IgE

CD8+ (if protozoa are within cells)

Question 16

Parasite strategies to escape immunity (3)

Answer 16

Some of them survive within cells
Cyst formation
Tegumantum resist Ab

Question 17

MPH cahanges induces by Helminth

Answer 17

NeMac MPH phenotype (M2)

Question 18

Helminth secretes ___ to inhibit MPH

Answer 18

MPH Inhibiting Factor

Question 19

Patient’s blood with parasite will contain

Answer 19

IgE

Eosinophilia

Question 20

Innate immunity to Fungi (3)

Answer 20

Fungicis ROS
Lysosomal enzymes
Phagocytosis

Question 21

PAMP of Fungi (3)

Answer 21

Zysoman
Mannan
B-glycan

Question 22

DC secrete __ to recruit __ and ___

Answer 22

IL23

Th17 and ILC3

Question 23

Adaptive immunity to Fungi?

Answer 23

Th1
Th17
+ Same as to IC bacterias

Question 24

Strategies of Fungi to escape immunity

Answer 24

Unknown

Question 25

Blood of patient with Fungi

Answer 25

Neutrophilia | When chronic, also Monocytosis

Question 26

Innate immunity against Viruses | Type 1

Answer 26

IFN-a | IFN-b

Question 27

IFN-a are produced by

Answer 27

Leukocytes

Question 28

IFN-b are produced by

Answer 28

Fibroblasts

Question 29

Innate immunity against Viruses | Type 2

Answer 29

IFN- gamma

Question 30

IFN- gamma are produced by

Answer 30

NK cells (ICL1)

Question 31

Viruses PAMP recognition (3)

Answer 31

GP by TLR2,4 DNA by TLR9 RNA by TLR3, 7/8

Question 32

Adaptive immunity to Viruses

Answer 32

Th2 secrete Ab | Prevent spread

Question 33

Cellular immunity to viruses by

Answer 33

CD8+ T cells and CD4+ Th1 cells

Question 34

Which cytokines provide early defense against viruses infection? (3)

Answer 34

TNF-a IL12 IFN-a

Question 35

Stractual plasticity is achieved by (2)

Answer 35

Ag drift | Ag shift

Question 36

Ag drift

Answer 36

After virus passage in the host, slightly modified Ag appears

Question 37

Ag shift

Answer 37

New gene bcs gene exchange btw two viruses

Question 38

HIV effect on Immunity

Answer 38

Induces internalization of CD4 and MHC1/2

Question 39

EBV effect on Immunity

Answer 39

Physical blocking of MHC2

Question 40

HIV-1 increases ___ expression of the infected cell

Answer 40

FasL

Question 41

Tissues with no inflammation

Answer 41

CNS and eyes

Question 42

Virus infected patients will have ____ in their blood

Answer 42

Lymphocytosis

Question 43

Secondary immuno deficiency is __% of all immuno deficiency

Answer 43

90%

Question 44

Primary immuno deficiency of T cell examples

Answer 44

SCID | DiGeorge

Question 45

Primary immuno deficiency of Phagocytes examples

Answer 45

Chronic granulomatous disease

Question 46

Hyper IgM syndrome- what we will see

Answer 46

Patient is unable to switch IgM to IgG, IgA, IgE Recurrent pyogenic infection

Question 47

Cause of Hyper IgM syndrome

Answer 47

Lack of T cell CD40L

Question 48

Job of CD40L

Answer 48

Induces class switch

Question 49

Classical pathway deficiency leads to

Answer 49

Immuno-complex disease

Question 50

MBL pathway deficiency leads to

Answer 50

Bacterial infections mainly in childhood

Question 51

Alternative pathway deficiency leads to

Answer 51

Neisseria and Pyogenic infections

Question 52

____ drops below threshold in AIDS

Answer 52

CD4+