Pathogens and Host - Immunity Flashcards Preview

Principles of Disease > Pathogens and Host - Immunity > Flashcards

Flashcards in Pathogens and Host - Immunity Deck (23):
1

What type of phagocytic cell is acute - short lived?

Polymorphs

2

What type of phagocytic cell is chronic - long lived?

Macrophages

3

Where can you find fixed macrophages?

Liver, spleen, lymph nodes

4

What are the three types of polymorphs?

Neutrophils
Eosinophils
Basophils

5

What type of organisms are resistant to intracellular killing?

Capsulate organisms

6

The spleen clears the blood, what does the liver clear?

Entero-hepatic circulation

7

Do phagocytes have receptors for antibodies and complement?

Yes both, used in opsonisation

8

What immunoglobulin is responsible for the primary response?

IgM

9

What immunoglobulin is responsible for the secondary response?

IgG

10

What immunoglobulin is responsible for mucosal activity?

IgA

11

What immunoglobulin is responsible for allergic response?

IgE

12

What is an immunoglobulin?

A protein with antibody activity

13

What is another word for effector B cells that produce antibodies?

Plasma Cells

14

What is the effect of the activation of the helper T cell on the B cell?

Causes the B cell to differentiate into memory cells and effector B cells (plasma cells)

15

What triggers compliment?

Antibody - IgG or IgM only and its specific antigen

16

How are antobodies useful in fighting an infection?

Neutralises bacterial toxins (tetanus), viruses in viraemic stage, prevents adherence of microorganisms, opsonises capsulate organisms
Useful means of diagnosis

17

What type of organism can compliment lyse?

Gram negative organisms

18

How can complement attract polymorphs?

Complement cascade by-products are chemotactic

19

What are the different aspects of humoral immunity?

Mediated by macromolecules found in the extracellular fluids - including antibodies and compliment - usually responds to bacterial infection - causes inflammation

20

How do macrophages stimulate T cells?

They are antigen presenting cells

21

Which T cells are responsible for cytokine release?

Helper T cells

22

What do CD4 Th2 cells control?

B cell antibody response

23

Give an example of a bacteria that is capable of resisting intracellular killing

Mycobacterium tuberculosis