Flashcards in Pathogens and Host - Immunity Deck (23):
What type of phagocytic cell is acute - short lived?
What type of phagocytic cell is chronic - long lived?
Where can you find fixed macrophages?
Liver, spleen, lymph nodes
What are the three types of polymorphs?
What type of organisms are resistant to intracellular killing?
The spleen clears the blood, what does the liver clear?
Do phagocytes have receptors for antibodies and complement?
Yes both, used in opsonisation
What immunoglobulin is responsible for the primary response?
What immunoglobulin is responsible for the secondary response?
What immunoglobulin is responsible for mucosal activity?
What immunoglobulin is responsible for allergic response?
What is an immunoglobulin?
A protein with antibody activity
What is another word for effector B cells that produce antibodies?
What is the effect of the activation of the helper T cell on the B cell?
Causes the B cell to differentiate into memory cells and effector B cells (plasma cells)
What triggers compliment?
Antibody - IgG or IgM only and its specific antigen
How are antobodies useful in fighting an infection?
Neutralises bacterial toxins (tetanus), viruses in viraemic stage, prevents adherence of microorganisms, opsonises capsulate organisms
Useful means of diagnosis
What type of organism can compliment lyse?
Gram negative organisms
How can complement attract polymorphs?
Complement cascade by-products are chemotactic
What are the different aspects of humoral immunity?
Mediated by macromolecules found in the extracellular fluids - including antibodies and compliment - usually responds to bacterial infection - causes inflammation
How do macrophages stimulate T cells?
They are antigen presenting cells
Which T cells are responsible for cytokine release?
Helper T cells
What do CD4 Th2 cells control?
B cell antibody response