Pathology 3

Question 1

Lymphoid or myeloid neoplasms with widespread involvement of BM. Tumor cells in peripheral blood.

Answer 1

Leukemia

Question 2

Discrete tumor masses arising from LN.

Answer 2

Lymphoma

Question 3

Acute inflammatory response to infection.

Answer 3

Leukemoid reaction, increased WBC count with left shunt and increase leukocyte ALP

Question 4

Reed-Sternberg Cells

Answer 4

Hodgkin Lymphoma

Question 5

Localized, single group of nodes; contiguous spread

Answer 5

Hodgkin Lymphoma

Question 6

Bimodal Distribution

Answer 6

young adulthood and >55y/o

Hodgkin Lymphoma

Question 7

Associated with EBV

Answer 7

Hodgkin Lymphoma

Question 8

Most common subtype of Hodgkin Lymphoma

Answer 8

Nodular Sclerosis

Question 9

Peak age for NHL

Answer 9

20-40

Question 10

IgM heterophile Antibody (+)

Answer 10

Infectious Mononucleosis

Question 11

Confirmatory test for Infectious mononucleosis

Answer 11

EBV viral Capsid Antigen

Question 12

CD15+ and CD30+

Answer 12

Reed-Sternberg in HL

Question 13

t(8;14)

Answer 13

translocation of c-myc and heavy-chain Ig

Burkitt Lymphoma

Question 14

Starry Sky

Answer 14

sheets of lymphocytes with interspersed macrophages
Burkitt Lymphoma (NHL)

Question 15

Endemic Burkitt Lymphoma

Answer 15

Jaw Lesion

Question 16

Sporadic Burkitt Lymphoma

Answer 16

Pelvis or Abdomen

Question 17

t(14; 18)

Answer 17

Follicular Lymphoma (bcl-2 activation)
Diffuse large B cell Lymphoma - most common NHL

Question 18

t(11; 14)

Answer 18

Translocation of cyclin D1 and heavy chain Ig
Mantle cell lymphoma
CD5+

Question 19

Lytic bone lesions, hypercalcemia, caused by HTLV-1

Answer 19

Adult T-cell Lymphoma

Question 20

Lymphocytes with cerebriform nuclei

Answer 20

Mycosis fungiodes/ Sezary Syndrome

Question 21

Pautrier microabscesses

Answer 21

Aggregates of neoplastic T cells in epidermis

Question 22

Monoclonal Plasma Cell “fried egg appearance”

Answer 22

Mulitple Myeloma

Question 23

Hypercalcemia, renal insufficiency, anemia, bone lytic lesions

Answer 23

Multiple Myeloma

Question 24

Large amounts of IgG and IgA, most common primary tumor arising within bone in the elderly

Answer 24

Mutliple Myeloma

Question 25

Bence Jones protein

Answer 25

Multiple Myeloma

Question 26

Rouleaux Formation

Answer 26

RBCs stacked like poker chips, Multiple Myeloma

Question 27

IgM spike with no lytic bone lesions

Answer 27

Waldenstrom macroglobulinemia

Question 28

M-spike with no features of multiple myeloma, no lytic lesions, no hyper[Ca2+], no AL amyloid, no Bence-Jones Proteinuria

Answer 28

MGUS - monoclonal gammopathy of undetermined significance

Question 29

High Serum IL-6

Answer 29

Multiple Myeloma because of increased plasma cells

Question 30

neutrophils with bilobed nuclei typically seen after chemo

Answer 30

Pseudo-Pelger-Huet Anomaly

Question 31

Cancer Associated with Down's

Answer 31

Acute Lymphoblastic Leukemia/Lymphoma and AML

Question 32

TdT+, CD10+, In children <15y/o

Answer 32

ALL (B-cell type)

Question 33

Where ALL can spread to

Answer 33

CNS and testes

Question 34

Cancer with mediastinal Thymic Mass

Answer 34

T-cell ALL

Question 35

Smudge Cells

Answer 35

Chronic Lymphocytic Leukemia (CLL)

Question 36

Neoplastic Proliferative of Naive B cells | Co-express CD5 and CD20

Answer 36

CLL

Question 37

Mature B-cell tumor in elderly

Answer 37

Hairy Cell Leukemia

Question 38

Stains TRAP (tartrate-resistant acid phosphatase)

Answer 38

Hairy Cell Leukemia

Question 39

Dry Tap on aspiration

Answer 39

Hairy Cell Leukemia

Question 40

Tx of Hairy Cell Leukemia

Answer 40

2-CDA, cladribine which is an adenosine analog inhibiting adenosine deaminase

Question 41

Cells have filamentous hair-like projections

Answer 41

Hairy Cell Leukemia

Question 42

Auer Rods

Answer 42

Acute Myelogenous Leukemia

Question 43

Increased circulating myeloblasts on peripheral smear in adults

Answer 43

AML

Question 44

Responds to all-trans retinoic acid (ATRA)

Answer 44

Induces differentiation of myeloblasts, txs AML-M3

Question 45

Common presentation of AML

Answer 45

DIC

Question 46

Philadelphia Chromosome

Answer 46

t(9; 22) CML bcr-abl hybrid

Question 47

Tx for CML

Answer 47

Imatinib, inhibits bcr-abl TK

Question 48

t(15; 17)

Answer 48

M3 type of AML (responsive to ATRA)

Question 49

Alpha-fetoprotein

Answer 49

heptoma, germ cell neoplasms

Question 50

CEA

Answer 50

breast and colon Cancer

Question 51

CA125

Answer 51

Ovarian Cancer

Question 52

PSA

Answer 52

Prostate Cancer, more for follow-up than diagnosis

Question 53

Proliferation of monoblasts, lack MPO, blasts infiltrate gums

Answer 53

Acute Monocytic Leukemia

Question 54

Proliferation of megakaryoblasts, lack MPO, associated with Downs before 5y/o

Answer 54

Acute Megakayoblastic Leukemia

Question 55

Jenny I got your number

Answer 55

8675309