Pathology 3 Flashcards Preview

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Flashcards in Pathology 3 Deck (55):
1

Lymphoid or myeloid neoplasms with widespread involvement of BM. Tumor cells in peripheral blood.

Leukemia

2

Discrete tumor masses arising from LN.

Lymphoma

3

Acute inflammatory response to infection.

Leukemoid reaction, increased WBC count with left shunt and increase leukocyte ALP

4

Reed-Sternberg Cells

Hodgkin Lymphoma

5

Localized, single group of nodes; contiguous spread

Hodgkin Lymphoma

6

Bimodal Distribution

young adulthood and >55y/o
Hodgkin Lymphoma

7

Associated with EBV

Hodgkin Lymphoma

8

Most common subtype of Hodgkin Lymphoma

Nodular Sclerosis

9

Peak age for NHL

20-40

10

IgM heterophile Antibody (+)

Infectious Mononucleosis

11

Confirmatory test for Infectious mononucleosis

EBV viral Capsid Antigen

12

CD15+ and CD30+

Reed-Sternberg in HL

13

t(8;14)

translocation of c-myc and heavy-chain Ig
Burkitt Lymphoma

14

Starry Sky

sheets of lymphocytes with interspersed macrophages
Burkitt Lymphoma (NHL)

15

Endemic Burkitt Lymphoma

Jaw Lesion

16

Sporadic Burkitt Lymphoma

Pelvis or Abdomen

17

t(14; 18)

Follicular Lymphoma (bcl-2 activation)
Diffuse large B cell Lymphoma - most common NHL

18

t(11; 14)

Translocation of cyclin D1 and heavy chain Ig
Mantle cell lymphoma
CD5+

19

Lytic bone lesions, hypercalcemia, caused by HTLV-1

Adult T-cell Lymphoma

20

Lymphocytes with cerebriform nuclei

Mycosis fungiodes/ Sezary Syndrome

21

Pautrier microabscesses

Aggregates of neoplastic T cells in epidermis

22

Monoclonal Plasma Cell "fried egg appearance"

Mulitple Myeloma

23

Hypercalcemia, renal insufficiency, anemia, bone lytic lesions

Multiple Myeloma

24

Large amounts of IgG and IgA, most common primary tumor arising within bone in the elderly

Mutliple Myeloma

25

Bence Jones protein

Multiple Myeloma

26

Rouleaux Formation

RBCs stacked like poker chips, Multiple Myeloma

27

IgM spike with no lytic bone lesions

Waldenstrom macroglobulinemia

28

M-spike with no features of multiple myeloma, no lytic lesions, no hyper[Ca2+], no AL amyloid, no Bence-Jones Proteinuria

MGUS - monoclonal gammopathy of undetermined significance

29

High Serum IL-6

Multiple Myeloma because of increased plasma cells

30

neutrophils with bilobed nuclei typically seen after chemo

Pseudo-Pelger-Huet Anomaly

31

Cancer Associated with Down's

Acute Lymphoblastic Leukemia/Lymphoma and AML

32

TdT+, CD10+, In children <15y/o

ALL (B-cell type)

33

Where ALL can spread to

CNS and testes

34

Cancer with mediastinal Thymic Mass

T-cell ALL

35

Smudge Cells

Chronic Lymphocytic Leukemia (CLL)

36

Neoplastic Proliferative of Naive B cells
Co-express CD5 and CD20

CLL

37

Mature B-cell tumor in elderly

Hairy Cell Leukemia

38

Stains TRAP (tartrate-resistant acid phosphatase)

Hairy Cell Leukemia

39

Dry Tap on aspiration

Hairy Cell Leukemia

40

Tx of Hairy Cell Leukemia

2-CDA, cladribine which is an adenosine analog inhibiting adenosine deaminase

41

Cells have filamentous hair-like projections

Hairy Cell Leukemia

42

Auer Rods

Acute Myelogenous Leukemia

43

Increased circulating myeloblasts on peripheral smear in adults

AML

44

Responds to all-trans retinoic acid (ATRA)

Induces differentiation of myeloblasts, txs AML-M3

45

Common presentation of AML

DIC

46

Philadelphia Chromosome

t(9; 22) CML bcr-abl hybrid

47

Tx for CML

Imatinib, inhibits bcr-abl TK

48

t(15; 17)

M3 type of AML (responsive to ATRA)

49

Alpha-fetoprotein

heptoma, germ cell neoplasms

50

CEA

breast and colon Cancer

51

CA125

Ovarian Cancer

52

PSA

Prostate Cancer, more for follow-up than diagnosis

53

Proliferation of monoblasts, lack MPO, blasts infiltrate gums

Acute Monocytic Leukemia

54

Proliferation of megakaryoblasts, lack MPO, associated with Downs before 5y/o

Acute Megakayoblastic Leukemia

55

Jenny I got your number

8675309