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Flashcards in Physiology Deck (24):
1

Most common reason for failed blood transfusions

Clerical Error

2

Deficiency of factor VIII

Hemophilia A, X-linked recessive

3

Deep tissue, joint and post-Sx bleeding

Hemophilia A, X-linked

4

Deficiency of Factor IX

Hemophilia B, Christmas Disease

5

Inhibits enzyme vitamin K epoxide reductase

Warfarin

6

Vitamin K deficiency

decreased synthesis of factors II, VII, IX, X, protein C and S

7

Antithrombin inhibits activated forms of

factors II, VII, IX, X, XI, and XII

8

enhances the activity of antithrombin

Heparin

9

Changes Plasminogen into Plasmin

tPA

10

Factor V Leiden mutation

factor V resistant to inhibition by activated protein C

11

4 steps of Primary Hemostasis

1. Transient constriction of BVs
2. Plt adhesion to disrupted vessel
3. Plt Degranulation
4. Plt Aggregation

12

vWF

binds to exposed collagen upon endothelial damage

13

How to link Platelets

Fibrinogen binds GpIIb/IIIa receptors

14

Deficiency of GpIb

Bernard-Soulier Syndrome

15

Deficiency of vWF

von Willebrand disease

16

Abciximab

blocks GpIIb/IIIa

17

Deficiency of GpIIb/IIIa

Glanzmann Thrombasthenia

18

Irreversibly blocked by Clopidogrel and Ticlopidine

ADP receptor

19

Inhibits cyclooxygenase (TXA2 synthesis)

Aspirin

20

activates vWF to bind GpIb

Ristocetin, useful to diagnose vonWillebrand disease

21

Inhibit ADP-induced expression of GpIIb/IIIa

Clopidogrel and Ticlopidine

22

Increased ESR

infections, autoimmune diseases, malignant neoplasms, GI disease (UC), pregnancy

23

Decreased ESR

polycythemia, sickle cell anemia, CHF, microcytosis, hyperfibrinogenemia

24

Who you gunna call?

Ghostbusters!