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Flashcards in Pharmacology Deck (50):
1

Decreases thrombin and factor Xa

Heparin

2

Toxicity of Heparin

Bleeding, HIT, osteoporosis

3

Antidote for heparin

Protamine Sulfate

4

Enoxaparin and Dalteparin

LMW heparin, act more on factor Xa, better bioavailability

5

Explain HIT

development of IgG antibodies against heparin bound to platelet factor 4 (PF4)

6

Derivatives of hirudin, the anticoagulant used by leeches, inhibit thrombin directly

Argatroban, Bivalirudin

7

Affects extrinsic pathway and increases PT

Warfarin

8

Used after STEMI, venous thromboembolism prophylaxis and prevents stroke in atrial fibrillation

Warfarin

9

PT/INR

Warfarin

10

Fresh Frozen plasma

for rapid reversal of severe warfarin overdose

11

Vitamin K

reversal of warfarin overdose

12

Apixaban, Rivaroxaban, Fondaparinux

Direct Factor Xa inhibitors

13

Tx and prophylaxis of DVT and PE

Rivaroxaban (a direct factor Xa inhibitor)

14

PT or PTT corrected with mixing study

Patient has a factor deficiency

15

PT or PTT not corrected with mixing study

Standard plasma didn't correct blood, patient has a factor inhibitor

16

Site of action for Warfarin

Liver

17

Deficiency in Protein C or S

Warfarin causes tissue necrosis

18

Alteplase

Thrombolytic

19

Directly or indirectly aid conversion of plasminogen to plasmin

Alteplase (tPA)

20

C/I of Thrombolytics

Cerebral hemorrhage, bleeding diatheses, or severe HTN

21

Tx of Thrombolytic Toxicity

Aminocaproic Acid

22

Irreversibly inhibits cyclooxygenase by covalent acetylation

Aspirin

23

Clinical Effects of Aspirin

Antipyretic, Analgesic, Anti-inflammatory, antiplatelet

24

Reye Syndrome in children with Viral infection

Aspirin

25

Gastric Ulcerationand tinnitis

Aspirin toxicity

26

Thienopyridines

Clopidogrel, Ticlopidine, Prasugrel, ADP receptor inhibitors

27

Non-thienopyridine

Ticagrelor, reversible ADP receptor inhibitor

28

Inhibit platelet aggregation by irreversibly blocking ADP receptors this inhibiting fibrinogen binding by preventing gpIIb/IIIa from binding fibrinogen

Thienopyridines - Clopidogrel, Ticlopidine, Prasugrel

29

C/I for Prasugrel

>75y/o, Hx of TIA or CVA, weighs <60kg

30

A/E of Ticlopidine

TTP and neutropenia

31

Ued for acute coronary syndrome and coronary stenting

ADP receptor inhibitors (clopidogrel and Prasugrel)

32

Pro-drug that needs CYP-2C19 (30% pop are poor responders)

Clopidogrel

33

Phosphodiesterase III inhibitor, increase cAMP in platelets to inhibit aggregation

Cilostazil, dipyridamole

34

Used for Intermittent claudication

Cilostazil, dipyridamole

35

Toxicity of Cilostazil, dipyridamole

nausea, HA, facial flushing, hypotension, abdominal pain

36

GP IIb/IIIa inhibitors

Abciximab, Eptifibatide, tirofiban

37

Used for Unstable angina, percutaneous transluminal coronary angioplasty

Abciximab, Eptifibatide, tirofiban

38

Agent used to treat myocardial infarction (MI) and to reduce incidence of subsequent MI

Aspirin

39

Antiplatelet drug reserved for patients allergic to aspirin

Ticlopidine

40

Side effect for ticlopidine

Neutropenia and agranulocytosis

41

Irreversible inhibitor of platelet P2Y12 receptors; effective in preventing transient ischemic attack

Clopidogrel and ticlopidine

42

Route of administration of warfarin

Oral

43

Contraindication of warfarin

Pregnancy

44

Anticoagulant of choice in pregnancy

Heparin

45

Heparin (PTT) increases activity of

Antithrombin 3

46

Routes of administration of heparin

IV and SC

47

Two anticoagulant used for prophylaxis and treatment of thrombosis in patients with heparin-induced thrombocytopenia

Bivalirudin, argatroban

48

Side effect of tissue plasminogen activators

Cerebral hemorrhage

49

Indications for thrombolytics

Pulmonary embolism, severe deep vein thrombosis

50

Thrombolytic that can cause allergic reaction and non-selective systemic fibrinolysis

Streptokinase