Pathology 4 Flashcards Preview

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Flashcards in Pathology 4 Deck (15):
1

Child with lyticc bone lesions and skin rash or recurrent otitis media with a mass involving mastoid bone

Langerhans Histiocytosis

2

Birbeck Granules

Tennis rackets on EM, Langerhans Histiocytosis

3

Letterer-Siwe Disease

Malignant proliferation of Langerhans cells, skin rash and cystic skeletal defects in infant <2y/o, multiple organs and rapidly fatal

4

Eosinophilic Granuloma

Benign proliferation of Langerhans cells in bone. Fz in adolescent, no rash. Bx with inflammation and EOSINOPHILS

5

Hand-Schuller-Christian Disease

Malignant proliferation of Langerhans, scalp rash, lytic skull defects, diabetes insipidus and exopthalmos in child (kids >3y/o)

6

Mutation in JAK2

Polycythemia Vera

7

Intense Itching After a hot shower

Polycythemia Vera

8

Tx of Polycythemia Vera

Phlebotomy and secondarily use Hydroxyurea

9

Complications of Polycythemia Vera

Urecemia and gout

10

Enlarged Megakaryocytes, mutation in JAK 2 kinase, Overproduction of abnormal platelets

Essential Thrombocytosis

11

Fibrotic Obliteratino of BM , Teardrop RBCs and immature forms of myeloid line

Myelofibrosis

12

Relative Polycythemia

decreased plasma volume from dehydration or burns

13

Appropriate Absolute Polycythemia

lung disease, congenital heart disease, high altitude

14

Inappropriate absolute polycythemia

renal cell carcinoma, Wilms tumor, cyst, hepatocellular carcinoma, hydronephrosis, due to ECTOPIC EPO

15

Who is a stupid clinical coordinator

Rita