Pharmacology 2 Flashcards Preview

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Flashcards in Pharmacology 2 Deck (14):
1

Describe some of the sources of drugs?

Natural products from nature
Synthetic drugs from the pharmaceutical industry
Biotechnology using living systems to make therapeutic agents.
Gene therapy

2

How do drugs act?

Interfering with a binding site - a receptor

3

Give examples of binding sites

Cell surface and intracellular receptors
Ion channels
Carriers
Enzymes
Nucleic acids

4

When will you get the maximum response from a drug?

When all the relevant receptors are bound to the drug

5

What is the affinity of a drug?

It is the strength of chemical attraction between the drug and the receptor

6

Why is the concentration / response graph curved?

Because it is more likely for a ligand to hit a free receptor at the start of a reaction then the end

7

What graph is used to determine the EC50?

The log of drug concentration against the increasing response

8

What is the EC50?

It is the concentration of a drug at half of its maximal response

9

What does the EC50 indicate?

The affinity of the drug for the receptor, a smaller EC50 indicates a smaller amount of drug is needed to evoke the same response, therefore the drug has a higher affinity

10

What does efficacy determine?

It determines how good the drug is at activating the receptor

11

How does efficacy affect the EC50

It doesn't

12

What is an agonist?

It mimics the normal effect of the receptor

13

What is an antagonist?

It blocks the normal effect of the receptor

14

How many different receptors can a strand of drug bind to?

As many as the drug has conformational shapes to the receptor