Pharmacology Flashcards
What receptors cause bronchial smooth muscle contraction?
M3 muscarinic ACh receptors
What do vasoactive intestinal peptide and NO do?
Relax BSM
What pathological changes occur in asthma?
Hypertrophy and hyperplasia of BSM
Oedema
Increased music secretion
Epithelial damage
What fibres are exposed due to epithelial damage?
C-fibres
What effect does increased hyperreactivity have on an asthmatics FEV1?
More pronounced fall in FEV1
What are the early and late phases of an asthma attack?
Early - bronchospasm
Late - inflammation
What cells do Th0 cells mature into in a non-asthmatic?
Th1
In what people are Th2 cells produced?
In asthmatics
What interleukin promotes B cell proliferation in asthma?
IL-4
What cells does IL-5 activate in asthma?
Eosinophils
What is released from mast cells in asthma?
Secretory granules - Preformed histamine - Leukotrienes produced (LTC4 and LTD4) Chemotaxins - Platelet activation factor - Prostaglandins
What a re some causes of non-allergic rhinitis?
Infection Hormonal imbalance Vasomotor disturbances Non-Allergic Rhinitis with Eosinophil Syndrome Medications
What type of innervation is dominance in controlling bronchial smooth muscle tone?
Cholingeric (PNS)
