Flashcards in Pharmacology Deck (13):
What receptors cause bronchial smooth muscle contraction?
M3 muscarinic ACh receptors
What do vasoactive intestinal peptide and NO do?
What pathological changes occur in asthma?
Hypertrophy and hyperplasia of BSM
Increased music secretion
What fibres are exposed due to epithelial damage?
What effect does increased hyperreactivity have on an asthmatics FEV1?
More pronounced fall in FEV1
What are the early and late phases of an asthma attack?
Early - bronchospasm
Late - inflammation
What cells do Th0 cells mature into in a non-asthmatic?
In what people are Th2 cells produced?
What interleukin promotes B cell proliferation in asthma?
What cells does IL-5 activate in asthma?
What is released from mast cells in asthma?
- Preformed histamine
- Leukotrienes produced (LTC4 and LTD4)
- Platelet activation factor
What a re some causes of non-allergic rhinitis?
Non-Allergic Rhinitis with Eosinophil Syndrome