Pharmacology Flashcards Preview

Year 1 - Respiratory (DP) > Pharmacology > Flashcards

Flashcards in Pharmacology Deck (13):
1

What receptors cause bronchial smooth muscle contraction?

M3 muscarinic ACh receptors

2

What do vasoactive intestinal peptide and NO do?

Relax BSM

3

What pathological changes occur in asthma?

Hypertrophy and hyperplasia of BSM
Oedema
Increased music secretion
Epithelial damage

4

What fibres are exposed due to epithelial damage?

C-fibres

5

What effect does increased hyperreactivity have on an asthmatics FEV1?

More pronounced fall in FEV1

6

What are the early and late phases of an asthma attack?

Early - bronchospasm
Late - inflammation

7

What cells do Th0 cells mature into in a non-asthmatic?

Th1

8

In what people are Th2 cells produced?

In asthmatics

9

What interleukin promotes B cell proliferation in asthma?

IL-4

10

What cells does IL-5 activate in asthma?

Eosinophils

11

What is released from mast cells in asthma?

Secretory granules
- Preformed histamine
- Leukotrienes produced (LTC4 and LTD4)
Chemotaxins
- Platelet activation factor
- Prostaglandins

12

What a re some causes of non-allergic rhinitis?

Infection
Hormonal imbalance
Vasomotor disturbances
Non-Allergic Rhinitis with Eosinophil Syndrome
Medications

13

What type of innervation is dominance in controlling bronchial smooth muscle tone?

Cholingeric (PNS)