pharmacology: alcohols Flashcards Preview

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Flashcards in pharmacology: alcohols Deck (6)
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1

what do alcohols cause?

CNS depression (GABA mimetic activity) and metabolic acidosis

2

what is the treatment for overdose with methanol and ethylene glycol?

fomepizole (long acting inhibitor of alcohol dehydrogenase) - protects against metabolic acidosis

3

what drug interaction do alcohols have? effect?

metronidazole, chlorpropamide, griseofulvin mixed with alcohol cause dislfiram-like effects

4

what causes the effects of a hangover?

N/V, headache, hypotension caused by acetaldehyde

5

what does acetaldehyde toxicity cause?

increased sociability, gait disturbances, increased reaction time, ataxia, impaired motor and mental skills, impaired memory, coma, death

6

what does chronic alcoholism cause?

hypoglycemia, fatty liver/lipemia, muscle wasting, gout (lactate compete with urate for excretion)