Flashcards in pharmacology: alcohols Deck (6)
what do alcohols cause?
CNS depression (GABA mimetic activity) and metabolic acidosis
what is the treatment for overdose with methanol and ethylene glycol?
fomepizole (long acting inhibitor of alcohol dehydrogenase) - protects against metabolic acidosis
what drug interaction do alcohols have? effect?
metronidazole, chlorpropamide, griseofulvin mixed with alcohol cause dislfiram-like effects
what causes the effects of a hangover?
N/V, headache, hypotension caused by acetaldehyde
what does acetaldehyde toxicity cause?
increased sociability, gait disturbances, increased reaction time, ataxia, impaired motor and mental skills, impaired memory, coma, death