Flashcards in pharmacology: heart failure Deck (12)
pharmacotherapy aimed at what in CHF?
decreased preload, decreased afterload, increased contractility, decreased remodeling
which drugs decrease preload?
diuretics, ACEIs, ARBs, venodilators
which drugs decrease afterload?
ACEIs, ARBs, arteriodilators
which drugs increase contractility?
digoxin, beta agonists
which drugs decrease remodeling of cardiac muscle?
ACEIs, ARBs, spironolactone, beta blockers
inhibits cardiac Na-K ATPase (causes increased Ca, increased Ca release from SR, increased actin-myosin interaction, increased contractile force)
also increased vagal activity (same mechanism on nerve terminals)
CHF and supraventricular tachycardias
digoxin side effects
early signs: anorexia, nausea, EKG changes
later signs: disorientation, visual effects (halos), yellow-green distortion
toxic doses: cardiac arrhythmias
how is management of digoxin toxicity managed?
digoxin drug interactions?
diuretics: decreased K and Mg and increased Ca
quinidine and verapamil
inamironone and milrinone mechanism
phosphodiesterase inhibitors (increased cAMP = increased inotropy and vasodilation)