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Flashcards in pharmacology: heart failure Deck (12)
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1

pharmacotherapy aimed at what in CHF?

decreased preload, decreased afterload, increased contractility, decreased remodeling

2

which drugs decrease preload?

diuretics, ACEIs, ARBs, venodilators

3

which drugs decrease afterload?

ACEIs, ARBs, arteriodilators

4

which drugs increase contractility?

digoxin, beta agonists

5

which drugs decrease remodeling of cardiac muscle?

ACEIs, ARBs, spironolactone, beta blockers

6

digoxin mechanism

inhibits cardiac Na-K ATPase (causes increased Ca, increased Ca release from SR, increased actin-myosin interaction, increased contractile force)

also increased vagal activity (same mechanism on nerve terminals)

7

digoxin uses

CHF and supraventricular tachycardias

8

digoxin side effects

early signs: anorexia, nausea, EKG changes
later signs: disorientation, visual effects (halos), yellow-green distortion
toxic doses: cardiac arrhythmias

9

how is management of digoxin toxicity managed?

Fab antibodies

10

digoxin drug interactions?

diuretics: decreased K and Mg and increased Ca
quinidine and verapamil

11

inamironone and milrinone mechanism

phosphodiesterase inhibitors (increased cAMP = increased inotropy and vasodilation)

12

what are the sympathomimetics?

dobutamine and dopamine