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Flashcards in chromosomal translocations Deck (11)
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1

8;14

burkitt lymphoma c-myc activation

2

9;22

philadelphia chromosome CML - bcr-abl hybrid

3

11;14

mantle cell lymphoma - cyclin D1 activation

4

14;18

follicular lymphoma - BCL-2 activation

5

15;15

APL - M3 type of AML

6

what does APL respond to

all-trans retinoic acid

7

bcl-2 activation

14;18 - follicular lymphoma

8

cyclin D1 activation

11;14 - mantle cell lymphoma

9

BCR-ABL hybrid

CML 9;22

10

c-myc activation

8;14 burkitt lymphoma

11

where are the ig heavy chain genes?

chromosome 14 - constitutively expressed