Pharmacology: GLP-1 Receptor Agonists Flashcards Preview

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Flashcards in Pharmacology: GLP-1 Receptor Agonists Deck (12)
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1

what type of drug are GLP-1 receptor agonists

incretin, insulin secretagogues

2

what is the GLP-1 receptor agonists mechanism

GLP-1 like molecules modified to avoid the breakdown of DPP4, can also alter half life

3

how do GLP-1 receptor agonists need to be administered

injection, not orally

4

how does the pharmacological effect of GLP-1 receptor agonists compare to that of DPP4i

far greater then DPP4i

5

what action do GLP-1 receptor agonists have relevant to diabetes

act to promote insulin secretion in glucose dependant mechanism, also lowers glucagon(which is increased in T2DM)

6

what are some of the systemic actions of GLP-1 receptors

reduce appetite by acting on hypothalamus and act on intestine to reduce gastric emptying

7

how potent are GLP-1 receptors

quite potent, reduce HbA1c by arund 11-15mmol/mol

8

what effect do GLP-1 receptor agonists have on weight and BP

weight = 2-3kg loss
BP = lower

9

what is the most commonly used GLP-1 receptor agonist

Liraglutide

10

what are some of the side effects of GLP-1 receptor agonists

nausea, vomiting(improves after 6 weeks), gallstones risk increased

11

what effect do GLP-1 receptor agonists have on CV risk

have been shown to reduce CV mortality by 12-20% for some GLP-1 RAs

12

where do GLP-1 RAs fit in the step by step treatment of T2DM

second line in those with compelling reason to minimise hypoglycaemia, OR those with compelling reason to lose weight, OR if significant CV risk or disease