Pharmacology: Incretin Effect and Physiology Flashcards Preview

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Flashcards in Pharmacology: Incretin Effect and Physiology Deck (15)
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1

where does the word incretin come from

INtestinal seRCETion of INsulin

2

what are the 2 different types of incretin peptides and what are they released by

GIP = from K cells
GLP-1 = from L cells

3

what are GIP and GLP-1 broken down by

DPP-IV
(very short half life)

4

what are incretin peptides released in response to

nutrient stimuli

5

what is the result of incretin peptide secretion

increased insulin secretion when high blood glucose

6

what pathway of insulin secretion do sulphonylureas act via of insulin secretion

Triggering pathway

7

what pathway of insulin secretion do incretins act via

Amplifying pathway

8

what receptor does the Amplifying pathway act via, and what does activation result in

the GLP-1/GIP receptor - G protein coupled receptor
results in increased cAMP

9

what effect does increased cAMP have on the pancreatic beta cell

close Katp channel, moderate Ca2+ currents, acts directly on insulin secretory mechanism

10

what needs to be activated in order for the Amplifying pathway to take effect

the Triggering pathway, which is triggered by glucose or sulphonylureas

11

what is the net result of the Amplifying pathway

primarily augmentation of insulin secretion

12

describe the Triggering and Amplifying pathway in terms of hypoglycaemia

Triggering = can occur
Amplifying = no hypoglycaemia

13

what is the incretin effect

oral glucose induces greater insulin secretion than parental(non-gut) administration of IV glucose

14

what are the stimulatory nutrients for incretin hormones

glucose, amino acids, fatty acids

15

what is the principle incretin hormone and what is it secreted by

GLP-1, secreted by L cells in the gut