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Flashcards in Insulin Deck (10)
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1

what type of hormone is insulin

peptide hormone

2

describe the therapeutic window of insulin

extremely narrow

3

what cells secrete insulin

beta cells of pancreatic islets

4

what is the compound produced by beta cells which is then cleaved to form insulin, and what else does it form

proinsulin, the cleaving of which produces insulin and C(connecting) peptide

5

what are the 3 different regions of proinsulin

A chain, B chain(of insulin) and C peptide

6

what enzyme cleaves the proinsulin

calcium dependant endopeptidases PC2 and PC3

7

what bonds are found between the A and B chain of insulin

disulphide bridges

8

how can the properties of insulin be changed

by swapping/adding amino acids in the A or B chains of insulin to give a shorter or longer half life

9

what form of ultrafast/ultra short-acting insulin is most commonly used on the UK, and when would it be used

insulin lispro, used 15 mins after meals

10

what form of ultra long-acting insulin is most commonly used in UK, and when would it be used

Glargine, used as single bed time does