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Flashcards in Physiology 1 Deck (25)
1

Tracer for TBW

3H20

2

Tracer for ECF

Inulin

3

Tracer for plasma

Labelled albumin

4

V=D/C

Volume (litres) = Dose/Sample concentration

5

How do you measure water imbalance?

Changes in body fluid osmolarity

6

Sodium greatest concenctration ICF or ECF?

ECF
-lots of chlorine in ECF as well
(potassium in ICF)

7

Fluid shift?

Movement of water between the ICF and ECF in response to an osmotic gradient

8

Gain and loss of NaCl and change in volumes of ECF and ICF

ECF NaCl gain:
ECF ↑ ICF↓
ECF NaCl loss:
ECF ↓ ICF ↑

9

What happens with gain or loss of isotonic fluid?

e.g. 0.9% NaCl solution
= no change in fluid osmolarity
Change in ECF only

10

Primary anion of the ECF?

Chlorine

11

Primary cation of the ECF?

Sodium
(cation = positive)

12

When does electrolyte balance occur?

When rates of gain = rates of loss (lol)

13

> 90% of the osmotic concentration of the ECF results from the presence of ...?

sodium salts

14

What can happen if concentration of K+ falls?

Muscle weakness --> paralysis
Cardiac irregularities --> cardiac arrest

15

Plays a key role in establishing membrane potentials?

K+

16

Salt imbalance is manifested as changes in ...?

Salt imbalance is manifested as changes in extracellular fluid volume
(remember water was measured as changes in osmolarity)

17

ICF percentage of TBW?

67%

18

ECF percentage of TBW?

33%
(plasma makes 20% of this, Interstitial fluid makes 80% of this)

19

Main ions in the ECF?

Na+, Cl-, HCO3

20

Main ions in the ICF?

K+, Mg2+

21

Which ion is mainly present in the ECF and is therefore a major determinant of ECF volume?

Na+

22

You need to control this ion to prevent muscle weakness (--> paralysis) and cardiac irregularities (--> cardiac arrest)

K+

23

Regulation of what is important for the long-term regulation of blood pressure?

Extracellular fluid volume

24

Total body water of male?

60% of body weight

25

Total body water of female?

50% of body weight