Platelet Maturation

Question 1

Produced by the brain derived from platelets and endothelial cells

Answer 1

Serotonin

Question 2

Serotonin derived from what

Answer 2

Platelet and endothelial cells

Question 3

NC ration pf megakaryoblast

Answer 3

10:1

Question 4

Multiple nucleoli blue cytoplasm

Answer 4

Megakaryoblast

Question 5

Chromatin become coarse, ieegulaly shape nucleus

Answer 5

Promegakaryocyte

Question 6

NC ratio of promegakaryocyte

Answer 6

4:1-7:1

Question 7

Multiple nuclei no nucleoli

Answer 7

Mature megakaryocyte

Question 8

NC ratio of mature megakaryocyte

Answer 8

1:1

Question 9

Disintegrated cells surrounded by platelets

Answer 9

Metamegakaryocyte

Question 10

Life span of platelets

Answer 10

8-11 days

Question 11

Ration of platelets in circulation

Answer 11

2/3

Question 12

Ratio of platelet in the spleen

Answer 12

1/3

Question 13

Decrease platelets

Answer 13

Splenomegaly

Question 14

Nuclear dibision without cytoplasmic dibision

Answer 14

Endomitosis

Question 15

Thrombopoietin produced by

Answer 15

Liver and kidney

Question 16

Responsible for platelet adhesion and aggregation

Answer 16

Peripheral zone

Question 17

Fxns as the outer surface

Answer 17

Glycocalyx

Question 18

Consist 30 or more gycoprotein

Answer 18

Plasma mem

Question 19

3 parts pf peripheral zone

Answer 19

Glycocalyx, plasma mem, submembranous area

Question 20

Actin and myosin

Answer 20

Microfilaments

Question 21

Consist of that maintains the shape of platelet

Answer 21

Microtubules

Question 22

Responsible for clot retraction

Answer 22

Thrombostenin

Question 23

Parts of organelle zone

Answer 23

Dense granules

Mitochondria, lysosomal granules

Question 24

Fxns as release of granules

Answer 24

Open canalicular system

Question 25

Parts of membranous system

Answer 25

Dense tubular system and open canalicular system

Question 26

Platelet adherence or expose sub endothelial surface/collagen

Answer 26

Adhesion

Question 27

Adhesion occur in the presence of what

Answer 27

Von willebrands factor

Question 28

Due to lack of von willebrand factor

Answer 28

Von willebrand disease

Question 29

Deficient of gp16

Answer 29

Bernard soulier disease/ giant platelet syndrome

Question 30

Acts as von willebrand factor

Answer 30

Gp16

Question 31

Morphologic and fucntion changes in platelet

Answer 31

Activation

Question 32

Subs that stimulate activation

Answer 32

Agonist

Question 33

Stimulate platelet secretion

Answer 33

Thromboxane A2

Question 34

Inhibit cyclooxygenase

Answer 34

Aspirin

Question 35

Release of grabules

Answer 35

Secretion

Question 36

Alpha granule deficiency

Answer 36

Gray platelet syndrome Chediak higashi Wiskott aldrich syndrome

Question 37

Dense granile deficiency

Answer 37

Hermansky pudlak

Question 38

Triad of immunodeficency, casuse thrombocytopenia and eczema

Answer 38

Wiskott aldrich syndrome

Question 39

Deficiency of factor V

Answer 39

Quebec platelet disorder

Question 40

Platelet attachmemt to each other

Answer 40

Aggregation

Question 41

Aggregation requires

Answer 41

Fibrinogen and calcium

Question 42

Deficiency of gpIIb

Answer 42

Glanzmann thrombosthenia

Question 43

Maturation sequence of megakaryoblast takes about 5 days. Platelet are produced firectly from the megakaryocytes clusters of granules aggregates from platelet

Answer 43

Platelet maturation sequence