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Flashcards in Platelets Deck (12):
1

What are the 4 functions of platelets

1. Maintenance of vascular integrity by sealing minor endothelial deficiencies.
2. Helping to arrest bleeding by the formation of platelet plugs following endothelial constriction.
3. Contributing membrane lipid procoagulant activity to facilitate secondary hemostasis (coagulation) and fibrin formation. ( platelet factor 3)
4. Promoting vascular healing through platelet derived growth factor (PDGF).
and smooth muscle production.

2

Where are platelets produced

 produced in the bone marrow from megakaryocytes.
Formed by megakaryocytic cytoplasmic demarcation.

3

What does thrombopoietin do

Regulates the development of megakaryocytes from hemopoietic stem cells.

4

Where is thrombopoietin produced

The source of thrombopoietin is uncertain but appears to involve liver, endothelial cells, and fibroblasts.

5

How long do platelets live

Platelets have a variable but finite intravascular lifespan in the dog and cat of 3 to 7 days.


6

How are platelets destroyed

    Effete platelets are phagocytized by macrophages of the mononuclear phagocyte system.

7

What is a decreased platelet count called

Thrombocytopenia

8

What is the name of Platelet Function Disorders

Thrombocytopathia or Thrombopathia

9

What can cause thrombocytopathia

Von Willebrands and NSAIDS

10

What is MPV

mean platelet volume

11

What is PCT

platelet crit

12

What is PDW

platelet distribution width