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Flashcards in Wbc Deck (45):
1

What are the two agranulocyte

Lymphocyte, monocyte

2

What is the function of the neutrophil

First responder against microbes

3

What does neutrophils in tissue cause

Pus

4

When neutrophils leave circulation how long did they stay in blood

10 hours then go into tissues

5

How long do neutrophils survive in tissues

1 to 4 days then undergo apoptosis

6

What can cause prolonged neutrophil lifespan

Cushing's disease or steroid therapy

7

How Do neutrophils migrate to tissue

Diapedesis

8

How do dogs react

Physiologic neutrophilia

9

How do cats react

Physiologic lymphocytosis

10

What are the signs of a regenerative left shift

Leukocytosis and more mature neutrophils then immature

11

What are the signs of a degenerative left shift

Child soldiers. Less mature than immature and a leukopenia

12

What are the names of the immature neutrophils

Band neutrophils, myelocyte, metamyelocyte

13

What is a hypersegmented neutrophils

Neutrophil with five or more lobes

14

What are five types of toxic neutrophil

Cytoplasmic basophilia, cytoplasmic vacuolation, Dohle bodies, cytoplasmic granulation, Bizzarre nuclear configuration

15

What are Dohle bodies

Basophilic leftover endoplasmic reticulum. We see them when there is a rapid turnover of cells. Often seen together with toxic granulation

16

What is toxic granulation

Found in severe inflammatory states. Thought to be due to impaired cytoplasmic maturation in effort to rapidly generate large numbers of granulocytes

17

What are some intracytoplasmic inclusions in the neutrophil due to

Canine distemper. Ehrlichia

18

What is Peter huet anomolye

Hypersegmentation of all granuolocytic nuclei

19

What is chediak higashi syndrome

Inherited disease
Fused granules

20

What is the Birman cat neutrophil anomaly

Neutrophils have eosinophilic granules

21

What is pelger huet anomaly

Is inherited as an incomplete dominant. Homozygous usually die in utero. Mainly in Australian shepherd

22

What are 3 causes of neutrophilia p

Physiologic or epinephrine induced
Corticosteroids or stress induced
Acute inflammation

23

What is neutrophilia

Counts exceed 12,000-13,000/ul

24

What is neutropenia

In dogs and cats, when the absolute count is less than 3000-4000 ul

25

How long does it take for bone marrow to generate an eosinophil

5-7 days

26

What are the functions of eosinophils

Systemic hypersensitivity reactions
Elimination of parasites

27

When do you see eosinopenia

When cortisol reduces the eosinophils

28

How long do basophils circulate the blood

For a few hours

29

How long do basophils live in the tissues

For a few weeks

30

What do basophil granules contain

histamine and heparin

31

what are monocytes

released into peripheral blood as immature cells and are transported to tissues where they can differentiate into macrophages, epitheloid cells, multinucleated inflammatory cells

32

what are the functions of the macrophages

phagocytosis
inflammatory response
antigen processing
regulation of body iron stores

33

monocytosis indicates

presence of inflammation
demand for phagocytosis
tissue necrosis
chronic inflammation

34

What are the three types of granulocytes

Neutrophils, basophils, eosinophils

35

What is the percent division of lymphocytes

70% Are T-lymphocytes and 30% are B lymphocytes

36

Are the two different types of lymphocytes distinguishable on the smear

No it is indistinguishable

37

What is the function of the lymphocyte

They're the cells of the specific immune system

38

What do b- lymphocytes differentiate into

Into plasma cells which produce antibodies (humoral immunity)

39

What do T lymphocytes do

Responsible for cellular immunity through the formation and release of molecules known as cytokines

40

What is lymphopenia

Reduction in the number of circulating lymphocytes

41

What is lymphopenia caused by

Viral infections, high circulating levels of glucocorticoids, cancer

42

What is physiologic lymphocytosis in cats cause by

Excitement

43

What is lymphocytosis do to antigenic stimulation

When inflammatory conditions are often associated with antigenic stimulation lymphocytosis an elevated globulins may result

44

What is lymphocytosis generally accompanied by

Marked non-regenerative anemia. Thrombocytopenia, neutropenia.

45

Describe atypical lymphocytes

Abnormal finding present in both infectious and neoplastic diseases