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Pharmacology 2240 > Pulmonary Drugs > Flashcards

Flashcards in Pulmonary Drugs Deck (36)
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1

Asthma, Lower respiratory infections (laryngotracheitis/bronchitis and pneumonia), Ventilator Support, and Smoking Cessastion

Pulmonary Diseases & Conditions

2

drugs used to relax bronchial smooth muscle (allow bronchioles to dilate to increase air flow and mitigate bronchospasm) to treat asthma, emphysema (COPD) and exercised-induced asthma (EIA);
can be given by mouth or injection, or nebulized as a liquid or powder

Bronchodilator drugs

3

triggered by acute infections, diseases like emphysema (COPD), part of asthma and EIA

bronchospasm

4

Sympathomimetic drugs, catecholamines
Stimulate beta-receptors in the smooth muscle around the bronchioles (mimic epinephrine) to relieve asthma
Use direct sympathetic stimulation to dilate bronchial smooth muscle
*includes epinephrine (prototype of mixed beta-1, 2 and alpha rc adrenergic agonist) and other non-selective sympathetic NS stimulants like cocaine, amphetamine, ephedrine, etc.

"Front door" bronchodilators (catecholamines)

5

causes bronchiole dilation

sympathetic stimulation
(sympathomimetic drugs or parasympatholytic drugs)

6

parasympatholytic drugs (anticholinergic, atropine-like drugs)
Produce effects complimentary to sympathetic agonists but by manner opposite of adrenergic agonists
Block the action of acetylcholine on muscarinic rc in smooth muscle around bronchioles
i.e. atropine or ipratropium

"Back door" bronchodilators

7

(chocolate, caffeine drugs, coffe)
Non-sympathetic
A group of drugs found to have bronchodilator effects, but not by mechanisms that manipulate the ANS
They act directly on the smooth around the bronchioles and the respiratory centers in the brain
Derived from a group of chemicals called xanthines (*methylxanthines are particularly useful)
*xanthine-type drugs include theophylline (Theo-Dur) found in black tea and caffeine in tea, coffee and soda

"Side door" bronchodilators

8

albuterol (Proventil, Ventolin): rescue therapy

-prototypical fast onset, short acting beta-2 selective bronchodilator
-is quick acting and lasts about 4-6 hours
-used as a rescue inhaler to treat acute wheezing

quick-acting bronchodilators better for every day use than epinephrine

9

salmeterol and formoterol: regular therapy

-2 good, long acting beta-2 agonists (LABAs)
-extended durations of action (up to 12 hours)
-take about a 1/2 hour to work
-used as preventative, prophylactic treatment
-work well as 'symptom-controllers' *good in combo with 2x/day corticosteroid (to be anti-inflammatory)

long-acting bronchodilators better for every day use than epinephrine

10

The prototype 'back-door' bronchodilator that has less cardiac effects than atropine and is longer acting; it's a metered dose inhaler or MDI

ipratropium

11

a dry-powder inhaler (DPI),
a metered-dose inhaler (MDI),
an oral tablet,
and an inhalation solution for use with
saline in a nebulizer machine

the 4 forms in which most beta-2 selective agonists are marketed and adminastered

12

Adrenergic drugs used to activate the alpha and beta receptors
-do not contain catechol in their nucleus
-i.e. ephedrine, phenylephrine, amphetamine, metatraminol and methoxamine
-used as treatment for various ailments like blood cell constriction, to get muscle relaxation, nasal and eye decongestion, and bronchiole dilation

Noncatecholamines

13

stimulate the beta 2 adrenergic receptors that cause bronchial smooth muscles to relax

"Front door" sympathomimetic bronchodilators

14

cause vasoconstriction

alpha receptors agonists

15

cause the heart rate to speed up

beta 1 receptors agonists

16

used preventatively

prophylactic

17

a popular combo of a beta 2 agonist (salmeterol) + a potent corticosteroid (fluticasone); easily inhaled as a powder (easier than using MDIs)

Advair (Sympathomimetic bronchodilator)

18

Singulair (montelukast), Accolate (zafirlukast) and Ultair (pranlukast)

Leukotriene rc blockers

19

white blood cells that release histamine, causing bronchoconstriction in an asthmatic or an allergy reaction in a person with hay fever

Mast cells

20

A series of shots aimed at producing 'blocking anitbodies' of the IgG type to prevent the IgE-allergen complex from causing mast cells to degranulate
(Basically a form of immunization against allergens)

Desensitization Immunotherapy

21

Group of drugs that suppress/reduce inflammation by suppressing almost all inflammatory products/mediators in the immune response
-NOT bronchodilators so they won't work for for acute situations of bronchoconstriction (won't relax bronchial smooth muscle)
-WILL dramatically decrease inflammation within 4-6 hours
(Inhibit part of the AA pathway)

Corticosteroids

22

examples of corticosteroid inhales excellent for maintenance therapy in asthma (to decrease acute attacks); side effects of locally inhaled are not as great as ones given systemically

beclomethasone (Vanceril MDI)
triamcinolone (Armacort MDI)

23

drugs used to treat URLs can also be used for ______

infections of the Upper Respiratory Tract

24

drugs that suppress cough and thin mucous secretions are used for pulmonary infections as well as __________

infections of the ear nose and throat

25

pen VK, amoxicillin, clarithromycin and azithromycin (macrolides), and ciprofloxacin/Cipro (fluoroquinolone)
*also used fro ENT infections

Oral antibiotics for lung infections (bronchitis, pneumonia)

26

Opioid cough suppressants and dextromethorphan (DXM)

best antitussive agents

27

most popular expectorant; found in Robitussin; comes from the guaiac tree

guaifenesin

28

Nicotine patch (NicoDerm), gum (Nicorette) and spray, Zyban, Chantix

Smoking Cessation drugs and therapies

29

remarketed antidepressant drug bupropion (Wellbutrin)
*found to have cured some people of the urge to smoke

Zyban

30

The newest andmost effective antismoking drug therapy:
-1st in a new compound class--blocks nicotine receptors in the brain
-allows the person to wean themselves off the effects of nicotine, still smoking for part of therapy
*has been linked to serious neuropsychiatric symptoms including suicidal ideation and erratic behavior

Chantix