rad bio test 1 review Flashcards
lymphocytes are what kind of cells?
mature
____ cells are the most radiosensitive
stem
what is the most sensitive in fetus?
what ever is developing
the ____ is less sensitive than the nucleus
cytoplasm
if there is no mylenated sheath, a cell cant ____
regenerate
cell proliferation
- act of single cell or grpup to ____ and multiply in number
reproduce
somatic cells vs gentic cells
mitosis
meosis ( genetic cells)
___ phase is most sensitive
S
which phase of mitosis can we study Rad response?
metaphase
G1,G2 phase is
- aka
gap- resting to get back energy
more o2 in tissue will produce ________
more damage
hieracrchy of cells
cells,tissues,organs,organ systems
bonding sequence
adenine-tymine
cytosine-guanine
direct and indirect hit
- most damage?
- Most damage from one time?
indirect hit because more frequent
direct hit more damage overall
the lethal effects of radiation are determined by observing cell ____ not cell ____
survival
death
ld 50/60
-p 507
%survival
_________
length survival
- 50% live for 60 days
hit is not simply an ionizing event but rather an ionization that inactivates the _____molecule that
target
sublethal vs lethal
sublethal repairs itself
- lethal -death
most energy at which two phases?
s,m
during between which to phases are least sensitive?
late s and m phase
Deterministic
aka
non stochastic
acute radiation syndromes p 505 read
prodromal latent hematologic GI CNS
prodromal
- dose
- signs
- less 1
- nausea , vomiting, diarhea
latent period
- dose
- signs
- 1-100GY
- none
Hematologic
- dose
- signs
- mean survival
- 2-10 GY
- nausea,vomiting,doarhea
- 10-60 days
GI
- dose
- signs
- mean survival
- 10-50 GY
- 4-10 days
- same as hematologic
CNS
- dose
- signs
- mean survival
- greater 50
- 0-3 days
- ataxia, edema, menigitis
ACUTE RAD Syndrome is _____
deterministic
With acute rad syndrome, which are you likely to survive with?
hematologic
ch 33 study skin issues
read
____ on skin keeps us from drowning and radiation causes a decrease this
keratin
Which two Acute rad syndrome are dose dependent?
hematopoietic, CNS
Acute Rad syndrome is not dose dependent?
GI
what acute rad syndrome has lowest survival rate?
CNS