Renal ADE for each class

Question 1

Which drug class can cause chronic renal impairment if used for a long time?

A) Opioids
B) Statins
C) Nonsteroidal anti-inflammatory agents
D) Metformin

Answer 1

C) Nonsteroidal anti-inflammatory agents
Rationale: Long-term use of nonsteroidal anti-inflammatory agents can lead to chronic renal impairment.

Question 2

Which drug is recognized as a risk factor for acute kidney injury in older people?

A) Fibrates
B) Statin
C) Metformin
D) Proton pump inhibitor

Answer 2

B) Statin
Rationale: Statins are recognized as a risk factor for acute kidney injury in the elderly.

Question 3

Which drug causes a reversible rise in serum creatinine values?

A) Fibrates
B) Opioids
C) Proton pump inhibitors
D) Aminoglycosides

Answer 3

A) Fibrates
Rationale: The adverse effect of fibrates is a reversible rise in serum creatinine values.

Question 4

Which antibiotic can lead to allergic interstitial nephritis, a type III hypersensitivity reaction?

A) Aminoglycosides
B) Fluoroquinolones
C) Tetracycline
D) Vancomycin

Answer 4

B) Fluoroquinolones
Rationale: Fluoroquinolones can cause allergic interstitial nephritis, a type III hypersensitivity reaction.

Question 5

Which drug is associated with nephrotoxicity after a single dose but recovers kidney function after cessation?

A) Aminoglycosides
B) Metformin
C) Opioids
D) Fibrates

Answer 5

A) Aminoglycosides
Rationale: Aminoglycosides can cause nephrotoxicity with a single dose, but kidney function typically recovers after cessation.

Question 6

Which drug class can lead to acute interstitial nephritis in acute settings?

A) Proton pump inhibitors
B) Opioids
C) Nonsteroidal anti-inflammatory agents
D) Statins

Answer 6

C) Nonsteroidal anti-inflammatory agents
Rationale: In acute settings, nonsteroidal anti-inflammatory agents can lead to acute interstitial nephritis.

Question 7

Which drug has a role in decreasing proteinuria in diabetic nephropathy patients?

A) Doxycycline
B) Vancomycin
C) Metformin
D) Aminoglycosides

Answer 7

A) Doxycycline
Rationale: Doxycycline, a type of tetracycline, has a role in decreasing proteinuria in diabetic nephropathy patients.

Question 8

Which drug is a protein synthesis inhibitor?

A) Aminoglycosides
B) Tetracycline
C) Fibrates
D) Opioids

Answer 8

B) Tetracycline
Rationale: Tetracycline is a protein synthesis inhibitor.

Question 9

Which drug class can cause acute kidney injury, chronic kidney injury, and end-stage renal disease?

A) Proton pump inhibitors
B) Statins
C) Opioids
D) Fibrates

Answer 9

A) Proton pump inhibitors
Rationale: Proton pump inhibitors can cause drug-induced allergic interstitial nephritis, acute kidney injury, chronic kidney injury, and end-stage renal disease.

Question 10

Which drug should have its dose adjusted in patients with kidney impairment to prevent accumulation?

A) Aminoglycosides
B) Metformin
C) Opioids
D) Statins

Answer 10

B) Metformin
Rationale: In patients with kidney impairment, it’s preferable to adjust the dose of metformin so it doesn’t accumulate.

Question 11

Which drug is associated with Vancomycin-induced nephrotoxicity?
A) Metformin
B) Tetracycline
C) Aminoglycosides
D) Vancomycin

Answer 11

D) Vancomycin
Rationale: Vancomycin is associated with Vancomycin-induced nephrotoxicity.

Question 12

Which drug class, when used concomitantly with quinolone antibiotics, may increase the risk of seizures?
A) Proton pump inhibitors
B) Nonsteroidal anti-inflammatory agents
C) Opioids
D) Statins

Answer 12

B) Nonsteroidal anti-inflammatory agents
Rationale: Nonsteroidal anti-inflammatory agents, when used with quinolone antibiotics, may increase the risk of seizures.

Question 13

Which drug’s long-term usage results in albuminuria?
A) Opioids
B) Statins
C) Fibrates
D) Metformin

Answer 13

A) Opioids
Rationale: Long-term usage of opioids can result in albuminuria.

Question 14

Which antibiotic is known to cause nephrotoxicity but recovers kidney function within 20 days of cessation?
A) Tetracycline
B) Aminoglycosides
C) Fluoroquinolones
D) Vancomycin

Answer 14

B) Aminoglycosides
Rationale: Aminoglycosides can cause nephrotoxicity, but kidney function typically recovers within 20 days of cessation.

Question 15

Which drug is a cell wall synthesis inhibitor?
A) Doxycycline
B) Aminoglycosides
C) Vancomycin
D) Fibrates

Answer 15

C) Vancomycin
Rationale: Vancomycin is a cell wall synthesis inhibitor.

Question 16

Which drug class can lead to a reversible rise in serum creatinine values?
A) Opioids
B) Statins
C) Fibrates
D) Proton pump inhibitors

Answer 16

C) Fibrates
Rationale: Fibrates can cause a reversible rise in serum creatinine values.

Question 17

Which drug can cause allergic interstitial nephritis within one week to two months of discontinuation?
A) Fluoroquinolones
B) Aminoglycosides
C) Tetracycline
D) Metformin

Answer 17

A) Fluoroquinolones
Rationale: Fluoroquinolones can cause allergic interstitial nephritis, and most cases resolve within one week to two months of discontinuation.

Question 18

Which drug is associated with decreasing proteinuria in diabetic nephropathy patients?
A) Doxycycline
B) Vancomycin
C) Aminoglycosides
D) Fibrates

Answer 18

A) Doxycycline
Rationale: Doxycycline has a role in decreasing proteinuria in diabetic nephropathy patients.

Question 19

Which drug class can cause acute interstitial nephritis in acute settings?
A) Statins
B) Opioids
C) Proton pump inhibitors
D) Nonsteroidal anti-inflammatory agents

Answer 19

D) Nonsteroidal anti-inflammatory agents
Rationale: In acute settings, nonsteroidal anti-inflammatory agents can lead to acute interstitial nephritis.

Question 20

Which drug should be dose-adjusted in patients with kidney impairment to avoid accumulation?
A) Opioids
B) Metformin
C) Aminoglycosides
D) Statins

Answer 20

B) Metformin
Rationale: In patients with kidney impairment, it’s preferable to adjust the dose of metformin so it doesn’t accumulate.

Question 21

Which drug class, when used with nonsteroidal anti-inflammatory agents, may enhance the neuroexcitatory effect?
A) Quinolones
B) Opioids
C) Statins
D) Proton pump inhibitors

Answer 21

A) Quinolones
Rationale: Quinolones may enhance the neuroexcitatory effect when used concomitantly with nonsteroidal anti-inflammatory agents.

Question 22

Which drug class can cause drug-induced allergic interstitial nephritis?
A) Proton pump inhibitors
B) Fibrates
C) Opioids
D) Statins

Answer 22

A) Proton pump inhibitors
Rationale: Proton pump inhibitors can cause drug-induced allergic interstitial nephritis.

Question 23

Which antibiotic is a protein synthesis inhibitor?
A) Aminoglycosides
B) Fluoroquinolones
C) Tetracycline
D) Vancomycin

Answer 23

C) Tetracycline
Rationale: Tetracycline is a protein synthesis inhibitor.

Question 24

Which drug is associated with an increased risk of seizure when used with nonsteroidal anti-inflammatory agents?
A) Quinolones
B) Metformin
C) Opioids
D) Statins

Answer 24

A) Quinolones
Rationale: Quinolones have an increased risk of seizure when used concomitantly with nonsteroidal anti-inflammatory agents.

Question 25

Which drug class can cause chronic kidney injury and end-stage renal disease? A) Proton pump inhibitors B) Opioids C) Fibrates D) Statins

Answer 25

A) Proton pump inhibitors Rationale: Proton pump inhibitors can cause chronic kidney injury and end-stage renal disease.

Question 26

Which drug class can lead to albuminuria with long-term use? A) Opioids B) Statins C) Nonsteroidal anti-inflammatory agents D) Proton pump inhibitors

Answer 26

A) Opioids Rationale: Long-term usage of opioids can lead to albuminuria.

Question 27

Which drug class is recognized as a risk factor for acute kidney injury in the elderly? A) Opioids B) Statins C) Fibrates D) Proton pump inhibitors

Answer 27

B) Statins Rationale: Statins are recognized as a risk factor for acute kidney injury in the elderly.

Question 28

Which drug class can cause a reversible rise in serum creatinine values? A) Opioids B) Statins C) Fibrates D) Proton pump inhibitors

Answer 28

C) Fibrates Rationale: Fibrates can cause a reversible rise in serum creatinine values.

Question 29

Which antibiotic can cause nephrotoxicity but recovers kidney function within 20 days of cessation? A) Tetracycline B) Aminoglycosides C) Fluoroquinolones D) Vancomycin

Answer 29

B) Aminoglycosides Rationale: Aminoglycosides can cause nephrotoxicity, but kidney function typically recovers within 20 days of cessation.

Question 30

Which drug should be dose-adjusted in patients with kidney impairment to avoid accumulation? A) Opioids B) Metformin C) Aminoglycosides D) Statins

Answer 30

B) Metformin Rationale: In patients with kidney impairment, it's preferable to adjust the dose of metformin so it doesn't accumulate.