Flashcards in Renal Cystic Disease Deck (16)
what adult age range is affected by polycystic kidneys ?
what are the two types of PCK?
PKD1 and 2
what mutation is PKD1?
Chr16, polycystin 1
what mutation is PKD2?
Chr4, polycystin 2:
what structures are affected in PKD1?
cell-cell and cell- matrix membrane receptor
what structures are affected in PKD2?
Ca2+ channel that interacts ̄c polycystin 1
what is the presentation of polycystic kidney disease? MISSHAPES
Mass: abdo mass and flank pain
Haematuria or haemorrhage into cyst
Aneurysms: berry → SAH
Polyuria + nocturia
Extra-renal cysts: liver
Systolic murmur: mitral valve prolapse
what medication is used to treat HTN in PKA?
what general measures can be taken for PKD?
↑ water intake, ↓ Na, ↓ caffeine (may ↓ cyst formation) Monitor U+E and BP
MRA (MRI and angiography) screen for Berry aneurysms
what is the inheritance of PKD?
what gender is medullary sponge kidney more common?
is renal function normal with medullary sponge kidney ?
is renal function normal with PKD?
- 70% ESRF at 70yrs
what are some DD for renal enlargement?
Polycystic kidneys: ADPKD, ARPKD, TS
Hypertrophy 2O to contralateral renal agenesis
Neoplasia: RCC, myeloma, amyloidosis
Occlusion (renal vein thrombosis)
Systemic: early DM, amyloid
what is tuberous sclerosis ?
AD condition ̄c hamartomas in skin, brain, eye, kidney