Respiratory diseases - sheep Flashcards

1
Q

What should you pay particular attention to when investigating a respiratory problem in sheep (often a flock problem)?

A
  • age
  • number affected
  • CS, progression and whether acute/chronic
  • time period
  • management
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2
Q

What should you pay particular attention to when doing a distance exam of a flock of sheep when you suspect a respiratory problem

A
  • demeanor
  • size heterogeneity
  • nasal/ocular discharge
  • signs of dyspnoea, resp distress
  • cough
  • particularly bad animals
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3
Q

What should you pay particular attention to when doing an individual sheep when you suspect a respiratory problem

A
  • temperature (normal is 38.8-39.9)
  • RR (normal is <20/min)
  • HR (normal is 70-80)
  • Size and BCS
  • MM and hydration status
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4
Q

Outline findings of the sheep respiratory system

A
  • abdominal respiration
  • normal RR <20/min (usually faster)
  • lung sounds may be loud
  • poor correlation between lung sounds an dpathology
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5
Q

How are most sheep respiratory diseases confirmed?

A

PME (£58.24 at APHA)

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6
Q

What tests can you do for sheep respiratory diseases

A
  • BAL (but consider commensals and significance of findings)

- valuable animals –> ultrasound or radiography

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7
Q

What do you need to decide when you have a respiratory problem on the farm?

A
  • risk to flock
  • contributing factors
  • short-term control
  • long term preventative strategy
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8
Q

What are the 5 broad categories of ovine respiratory disease?

A
  • sudden death
  • acute or sub-acute ill-health, cough, +/- discharges and fever
  • chronic ill thrift, occasional cough. lambs
  • chronic weight loss, breathing difficulties, adults
  • acute respiratory distress
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9
Q

What ovine respiratory disease is likely to cause sudden death?

A
  • Peracute pneumonia (M.haemolytica, ‘enzootic pneumonia’) –> septicaemia –> death (typically lambs, can be gimmers)
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10
Q

What ovine respiratory disease is likely to cause acute or subacute ill-health, cough +/- discharges and fever? 3

A
  • acute bacterial/viral pneumonias (fever)
  • aspiration pneumonia (fever)
  • parasitic pneumonia (fever)
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11
Q

What ovine respiratory disease is likely to cause chronic ill-thrift, occasional cough in LAMBS? 2

A
  • chronic pneumonia (Mycopl., resolved pneumonia) –> Lung damage –> poor weight gain
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12
Q

What ovine respiratory disease is likely to cause chronic weight loss and breathing difficulties in ADULT SHEEP?

A

‘Slow virus’ diseases (Maedi-Visna, SPA) –> lung tissue replaced with solid tissue. Only 1-2 animals affected at one time.

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13
Q

What ovine respiratory disease is likely to cause acute respiratory distress?

A

URT problem e.g. laryngeal constriction (Texels, Suffolks etc) or damage, laryngeal chondritis (due to high RR –> damage)

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14
Q

What is the most common respiratory problem in sheeP/

A
  • Ovine pneumonia. = enzootic pneumonia = pneumonic pasteurellosis*
  • Usually young animals
  • Endemic throughout UK
  • Multi-factorial aetiology
  • Predisposing factors (ventilation, age, stress)
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15
Q

What agents are principally involved in ovine pneumonia?

A
  • BACTERIA - especially M.haemolytica (also P. trehalosi, P.multocida, B.parpetussis, others)
  • MYCOPLASMAS
  • VIRUSES - especially PI3 and adenoviruses (also RSV and reoviruses)
  • Typically viruses cause the primary infection and bacteria and mycoplasmas follow secondarily*
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16
Q

Outline some risk factors involved in ovine pneumonia - 4

A

HOUSING - close contact, poor ventilation, high humidity
MIXING - ages (younger more vulnerable, up to 6mo and lambing ewes), sources
CLIMATE
STRESS - mixing, nutrition, housing

17
Q

CS - enzootic pneumonia - 5

A
  • sudden death possible
  • fever (>40.3)
  • depressed, not eating
  • dyspnoea, cough, nasal discharge (sometimes foamy)
  • death or poor thrift in recovered animals
18
Q

Is isolation of PI3 or M.haemolytica from nasal cavity diagnostic for enzootic pneumonia?

A

No - usually rely on Hx and CS (vary with chronicity). PME for definitive diagnosis. +/- histopath and culture of LARGE number of Mannheimia from the lung.

19
Q

How do you treat enzootic pneumonia in a.) outbreak b.) individual animals?

A

a. ) OUTBREAK - prophylactic LA oxytet (also used to reduce Chlamydophila so beaware of resistance issues) + vaccination
b. ) INDIVIDUAL - LA oxytet OR tilmicosin

20
Q

Outline prevention of enzootic pneumonia in sheep

A
  • Control of predisposing factors difficult

- Vaccination (doesn’t 100% protect against infection but reduces likelihood)

21
Q

Describe the common vaccination protocol for enzootic pneumonia for sheep (ewes and lambs)

A
  • EWE = sensitiser + booster 4-6 weeks later. Boost 4-6 weeks pre-lamb.
  • LAMB (MAb lasts about 3-5 weeks). Vaccinate at 3-5 weeks old, boost 3-4 weeks later.
22
Q

CS - atypical pneumonia

A
  • reduced growth rates*
  • occasional clinical case - dullness, reduced BCS
  • flock signs - cough, nasal discharge
  • death (rare)
23
Q

What are PME findings of atypical pneumonia? 3

A
  • clearly demarcated red-brown or grey areas of lung
  • typically affects apical and cardiac lobes
  • Mycoplasma ovipneumoniae
24
Q

Which parasites cause ovine parasitic pneumonia?

A
  • Dictyocaulus filaria* - the only important sheep lungworm
  • peak larval contamination in autumn and winter
  • lambs up to 1 yo affected
  • variation in susceptibility
  • non-pathogenic ovine lungworms are Muellerius and Protostrongylus
25
Q

CS - parasitic pneumonia 5

A
  • coughing
  • increased RR
  • nasal discharge
  • severe weight loss
  • death is rare
26
Q

Dx - parasitic pneumonia

A
  • Hx and CS
  • larvae in faeces
  • PME (adult worms clearly visible in bronchi, lesions usually in diaphragmatic lobes)
27
Q

Control - parasitic pneumonia

A
  • GIT parasite control measures (same anthelmintic susceptibility)
  • NO vaccine
28
Q

How important is sheep lungworm versus parasitic gastroenteritis?

A

No economic significance to farmers versus parasitic gastroenteritis. Severe lungworm infestations often seen in sheep with paratuberculosis (Johne’s) due to immunocompromise

29
Q

What is Maedi-Visna?

A
  • lentivirus
  • causes visna (wasting) and mastitis
  • TRANSMISSION - vertical (colostrum, milk, some horizontal transmission)
  • Introduced to UK in 70s, now >100,000 infected
  • Flock mortality about 2%
  • Premature culling
  • Reduced milk production
  • TAKES 3-4 YEARS TO DEVELOP CS AFTER INFECTION
30
Q

CS - Maedi-Visna - 6

A
  • animals usually 3yo+
  • SLOW progression of signs
  • emaciation
  • develops severe respiratory disease
  • +/- cough, nasal discharge
  • other flock problems - visna, mastitis, arthritis
31
Q

Dx - Maedi-Visna

A
  • Hx, CS
  • serology (individual or flock)
  • PME - voluminous lungs, uncollapsed, sink in water
32
Q

What does SPA stand for?

A

Sheep Pulmonary Adenomatosis = Ovine Pulmonary Adenomatosis (OPA) or ‘Jaagsiekte’

33
Q

Outline Sheep Pulmonary Adenomatosis (SPA)
Transmission
Mortality

A
  • retrovirus (slowly progressive lung adenocarcinoma, common contagious tumour)
  • long incubation
  • TRANSMISSION: respiratory and vertical, newly purchased sheep
  • MORTALITY: high in first instance, endemic –> losses of 2-10%
34
Q

CS - Sheep Pulmonary Adenomatosis (SPA)

A
  • adult sheep (usually 2-4 years)
  • progressive respiratory disease
  • weight loss
  • wheelbarrow test = pathognomonic = when hindquarters are lifted and the head lowered, fluid comes out of nostrils.
35
Q

Dx - Sheep Pulmonary Adenomatosis (SPA) - 4

A
  • Hx and CS
  • no serological tests
  • PME: tumours in lung, enlarged consolidated lungs, frothy fluid in bronchi
  • histopathology