Flashcards in Rodenticide Deck (37):
Is strychnine a weak acid or a weak base?
Which rodenticide is an alkaloid form strychnos nux vomica seeds?
Which rodenticide is a white powder with a bitter taste that is moderately water soluble?
How long can strychnine persist in the environment?
Up to 40 days
Which animals are susceptible to strychnine toxicity?
All animals are susceptible.
T/F: Cats are most frequently poisoned by strychnine and more sensitive than dogs.
False - Dogs most frequently poisoned by strychnine and more sensitive than cats.
What is a toxic dose of strychnine for dogs?
What is a toxic dose of strychnine for horses, cattle and pigs?
What is a toxic dose of strychnine for cats?
What is a toxic dose of strychnine for poultry?
Where is strychnine rapidly absorbed from?
What will decrease the toxicity of strychnine?
Food in the stomach may do what to the strychnine toxicity?
Increase or decrease toxicity
Does strychnine accumulate in a particular area?
Is strychnine highly protein bound?
Can strychnine cross the BBB?
Where is strychnine metabolized?
Excreted and in what form?
- Urine as both metabolites and unchanged toxin
Does strychnine undergo enterohepatic recirculation?
Most of a strychnine dose is eliminated in what amount of time?
About 24 hours
Which rodenticide blocks the post-synaptic effect of glycine in spinal cord?
What is an important inhibitory neurotransmitter to motor neurons and interneurons in the spinal cord, brainstem and thalamus?
What are 4 clinical signs that strychnine poisoning can lead to?
- Highly exaggerated reflex arcs
- Muscle spasm
- severe extensor rigidity
- Tonic seizures
How fast is the onset of strychnine toxicity?
Rapid onset: 10 mins-2 hours
What are 3 early signs of strychnine toxicity?
Mydriasis, stiffness, muscle twitching and hyperthermia are clinical signs of what rodenticide toxicity?
What do the clinical signs of strychnine poisoning progress to?
Tonic seizures and opisthotonos
What is opisthotonos?
Tetanic spasm in which spine and extremities are bent with convexity forward, the body resting on head and heels.
What is a clinical sign exhibited by dogs with strychnine poisoning?
Death from strychnine poisoning is due to what?
Are there lesions seen with strychnine poisoning?
Generally few or none
What are 4 antemortem specimens preferred for chemical detection of strychnine poisoning?
- Stomach contents
What 3 things are used to diagnose strychnine poisoning?
- Clinical signs
- Lab confirmation
What are the 2 main forms of treatment for strychnine poisoning?
- Supportive/symptomatic care
What are 2 forms of decontamination that can be used for strychnine poisoning?
- Emesis if not contraindicated
- Activated charcoal
Patients with strychnine poisoning may require what?
Sedation for 24-72 hours
What are 4 categories of drugs that should be avoided with strychnine poisoning?
- Neuromuscular blockers
- Dissociated anesthetics