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Flashcards in Salivary Control Pharm Deck (17):
1

xerostomia

mouth dryness

2

What types of drugs can induce xerostomia

Anti-depressants, anti-histamines, anti-psychotics, anti-HTN, anti-cholinergics, and decongestants

3

What are some short term causes of xerostomia

- drugs (just mentioned)
- dehydration (pretty obvious)
- anxiety
- MUMPS

4

Long term causes of dehydration

- drugs again
- Autoimmune diseases
- LIVER DISEASE

5

Consequence of xerostomia

dysphagia, difficulty speaking, oral lesions, taste alterations, halitosis (just bad breath)

6

SNS has what effect on salivary gland function

low volume/ high protein
Also constricts vessels of the salivary glands

7

This low volume/high protein response is mediated by which SNS receptor

Alpha1

8

Constrictin of the salivary gland vessels by the SNS is mediated by what

alpha1 and alpha 2

9

Parasympathetic nervous system leads to what effect on salivary flow

High volume/ low protein secretion (M3, M2) and dialates salivary gland vessels. It is important to note however that salivary vessels are not directly inervated by the PSNS so they are responding to circulating Ach and VIP.

10

Tx for xerostomia involves:

Muscarinic agonists, radioprotection, replacement

11

Cevimiline MOA

Muscarinic antagonistStimulates M3 receptors over M1s.

12

Adverse effects of Cevimiline>

Don't give to glaucoma pts, Asthma (PSNS M3 contracts bronchiolar smooth muscle), Iritis
Caution with heart, lung, pregnancy
May also lower cognition

13

MOA of Pilocarpine

muscarinic agonist (all receptors)

14

Adverse effects of Pilocarpine

same as Cevimiline

15

What is sialorrhea?

Hypersalivation

16

What causes sialorrhea?

Shit ton of drugs

17

How do you treat hypersalivation>

Anticholinergics (botox)