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Flashcards in Liver Function Test Deck (24):
1

Complications of Liver disease

- Synthetic impairment
- Cholestasis (decreased bile flow)
- Decreased Clearance
- Portal Hypertension (portal blood becomes shunted around the liver and not processed(

2

Where does Portal blood go?

Liver, ding dong

3

Liver Function Tests are really?

Liver enzyme measures...
More specifically, measures of hepatocyte injury or
impairment of bile flow.

4

When liver cells are injured, what is released into the blood

Aminotransferases and Alkaline Phosphatase (more commonly seen with Bile Duct Injury)
Testing for these substances tests for direct cell injury to the liver

5

Tests for clearance?

Bilirubin and Ammonia....both of these are made in the liver and both should be cleared.

6

Tests of synthetic capacity

-Clotting Factors (done by measuring prothrombin time or INR, one of the results of the clotting cascade)
- Albumin
- Cholesterol

7

What are the Aminotransferases

AST and ALT

Remember that AST can be associated with muscle injury as well
ALT more specific for liver

8

Aminotransferases measure what

liver injury

9

Alkaline phosphatase levels elevated suggests what

injury to bile duct

10

Alk Phos elevation also associated with injury to what other organs?

bone

11

Cholestasis can be intrahepatic or extrahepatic obstruction to bile flow

truth

12

Cholylglycine is what

A serum bile salt. Correlates with the degree of cholestasis present

13

GGT goes up with?

Bile duct impairment, tons of chemicals (dilantyn, ethanol)
Really not that helpful

14

Bilirubin made from what

Red cell turnover

15

Bilirubin is an imperfect measure of

hepatic clearance and excretory function

Goes up when clearance is reduced

16

Prothrombin time is prolonged when?

WHen clotting facters 1,2,5,7,10 are deficient or when Vitamin K is low

17

Albumin half life

around 20 days

18

Albumin is made in the liver

rapidly changes with illness and malnutrition

19

Look at child Pugh Score

ok

20

High creatinine in liver pts?

important

21

Ammonia is detoxified where and how?

Detoxified in the liver by the urea cycle and the glutamine synthetase rxn

22

Ammonia is high in what condition

hepatic encephalopathy

23

Child Pugh scoring:

Child A: score= 5-6
Child B: score= 7-9
Child C: score= 10-15

24

Model of End Stage Liver Disease score (MELD) looks at what

INR
Bilirubin
Creatinine