Inflammatory Bowel Disease Flashcards Preview

Gastrointestinal > Inflammatory Bowel Disease > Flashcards

Flashcards in Inflammatory Bowel Disease Deck (23):
1

Inflammatory Bowel Disease is defined as

a group of chronic inflammatory conditions of the colon and small intestine

2

Two major forms of IBD

Crohn's and Ulcerative Colitis

3

The Hygiene hypothesis is

Incidence of immune-mediated diseases is rising in developed countries and many scientists wonder whether it may be due to relatively good modern hygiene or lack of exposure to bacteria.

The data surrounding this and IBD is conflicting

4

What is ulcerative colitis?

Chronic inflammatory disorder of the GI tract affecting the large bowel. Features a dilated and thin colon whith severe inflammation

5

Where does ulcerative colitis start?

Begins in the rectum and extends proximally

6

What is seen on endoscopy with ulcerative colitis?

hyperemia (redness), edema, granularity, easy bleeding, broad based ulceration, pseudopolyps,rarely perforation

7

Toxic megacolon is?

shutdown of neuromuscular function secondary to exposure of fecal material to muscularis mucosa and neural plexus

8

Psuedopolyps=

ulcerative colitis

9

On microscopic pathology, ulcerative colitis is limited to what areas?

mucosal and submucosal layers. This is characteristic of ulcerative colitis

10

ulcerative proctitis

confined to rectum

11

In ulcerative proctitis rectal bleeding may be the only sign of the disease. May also have rectal pain, a feeling of urgency or inability to move bowels in spite of the urge to do so (tenesmus)

ok

12

Proctosigmoiditis

Involves the rectum and sigmoid. Bloody diarrhea, cramps, tenesmus

13

Left sided colitis

Disease extends from the rectum up the left side and through the sigmoid and descending colon. You would see bloody diarrhea, pain on left side, and wt loss

14

Wt loss first seen in what type of UC

Left sided

15

Pancolitis

Affects the entire colon.
You would see bouts of bloody diarrhea, abdominal cramps and pain, fatigue, wt loss

16

Fulminant Colitis

Uncommon, life-threatening, affects the entire colon.
Severe pain, profuse diarrhea, shock and dehydration, SIRS
Associated extensive and deep colonic injury

17

What does CT scan do well in regards to analysis of ulcerative colitis?

Evaluates free air and allows you to see other structures in the abdomen like mesenteric inflammation or lymphadenopathy

18

What does a CT scan do not do well?

Does not demonstrate mucosal detail which Barium studies can do

19

Crohn's disease involves what sections of the GI tract

Can involve any section though it has a propensity for distal small bowel and proximal colon. Can involve anywhere from mouth to anus. May see apthous ulcers in the mouth, esophageal ulcers, gastric disease, small bowel

20

Ways in which Crohn's is different than ulcerative

- rectal sparing (spares the rectum)
- Skip lesions
- Its very asymmetrical
- Deep ulcerations
- Stricture formation
- Fistula

21

Characteristics of Crohn's...

- Transmural involvement
- Noncaseating Granuloma
- Fissuring with Fistula
- Skip lesions

22

Cobblestone mucosa

Crohn's

23

Transmural lesion

Crohn's