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MY Bacteriology exam 2 > Shigella > Flashcards

Flashcards in Shigella Deck (16):
1

Shigella almost exculsively effects what species and where?

primates large bowel 

2

What is the most common species of Shigella?

Shigella dysenteriae

3

What is the most important virulence factor of Shigella dysenteriae?

Shiga toxin 

4

How does Shigella look under a microscope?

gram negative rod

A image thumb
5

What cells does the shigella adhere to in the large bowel?

M cells and epithelial cells

6

Shiga toxin disrupts ____ synthesis in the endothelial cells and causes cell death

protein 

7

What are the effector proteins that are injected via type III secretions from Shigella that induce lysis of phagocytes?

IpaB and IpaC

 

8

What effector proteins of Shigella help with mobility of shigella inside the cell

IcsA and IcsB 

*highjack the cytoskeleton 

9

how is shigella transmitted?

Fecal oral transmission 

*highly infectious

10

The presence of ____ will overcome Shigella

normal flora 

11

How does shigella survive in the PH of the stomach?

RpoS (RNS polymerase)

12

Shigella reaches the intestinal cells and destroy the mucus via the _____ attach to the M cells via the _____

destroys the mucus via the Pic

Attaches to the M cells mainly via the IpaD 

13

What does Shigella Dysenteria cause in primates?

hemorrhagic diarrhea and hemolytic uremic syndrome 

14

True/False: Antibody secretion is important for Shigella 

true

 

*They bind and protect the bacteria from adhering to the large bowel 

15

Case of african green monkey that is 15 years old in a very packed cage. Highly stressed out and starts presenting bloody diarrhea. What would the best differential be?

Shigella 

side note (Now you isolate a lactose positive organism and during a necropsy you find attaching and effasing lesions in the GI tract. What is the most likely agent now? Enterohemorragic E. coli)

Side note: (now you isolate a gram positive rod which is positive for the naglers test. What is the best differential? Clostridium perfringens)

16

What is the best treatment for Shigella?

prevention, nursing, and supportive care