Flashcards in Skin Deck (352)
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30
Tumid lupus: Histology.
Superficial and deep infiltrate that spares epidermis; increased dermal mucin.
31
Lupus panniculitis: Histology.
Lobular panniculitis with hyaline fat necrosis.
32
Subacute and neonatal lupus: Histologic differences from discoid lupus (3).
Subacute and neonatal lupus show
− Prominent changes at the D-E junction.
− Less hyperkeratosis.
− Less inflammation.
33
Cutaneous lupus: Immunofluorescence.
Continuous granular deposition of IgG, IgM, and C3 at the dermoepidermal junction.
34
Cutaneous lupus: How to distinguish from polymorphous light eruption.
PLE: More papillary dermal edema than tumid lupus; no dermal mucin.
35
Cutaneous lupus: Lymphoma that may be in the differential diagnosis.
Subcutaneous panniculitis-like T-cell lymphoma must be distinguished from lupus panniculitis.
36
Lupus band test.
Direct immunofluorescence . . .
Discoid lupus: Positive in lesional skin only.
Systemic lupus: Positive in "normal" skin as well.
37
Anatomic location:
A. Heliotrope rash.
B. Gottron's papules.
A. Eyelids.
B. Knuckles, knees, elbows.
38
Dermatomyositis may resemble which type of cutaneous lupus histologically?
Subacute lupus.
39
Dermatomyositis: Age group.
Children.
Adults aged 45-65.
40
Dermatomyositis: Immunofluorescence.
C5b-C9 around blood vessels.
41
Dermatomyositis: Lupus-band test.
Negative.
42
Id reaction:
A. Synonym.
B. Leading cause.
A. Autoeczematization.
B. Remote dermatophytosis.
43
Spongiotic dermatitis: Changes that indicate chronicity (3).
Epidermal hyperplasia.
Hyperkeratosis.
Papillary dermal fibrosis.
44
Seborrheic dermatitis: Histology (2).
Mild spongiosis.
Parakeratosis at follicular ostia.
45
Pityriasis rosea: Histology (3).
Focal spongiosis.
Mounds of parakeratosis.
Extravasated erythrocytes.
46
Eosinophilic spongiosis: Differential diagnosis (4).
Allergic contact dermatitis.
Bullous pemphigoid, early.
Pemphigus, early.
Incontinentia pigmenti.
47
Incontinentia pigmenti:
A. Inheritance.
B. Epidemiology.
A. X-linked dominant.
B. Mostly females.
48
Histology of incontinentia pigmenti: Vesicular stage (3).
Eosinophilic spongiosis.
Single dyskeratotic keratinocytes.
Whorls of squamous cells.
49
Histology of incontinentia pigmenti: Verrucous stage (4).
Hyperkeratosis.
Papillomatosis.
Dyskeratosis.
Occasional eosinophils.
50
Incontinentia pigmenti: Gene and its location.
IKBKG (a.k.a. NEMO) on Xp28.
51
Histology of incontinentia pigmenti:
A. Hyperpigmented stage.
B. Hypopigmented stage (3).
A. Many melanophages in the upper dermis.
B. Epidermal atrophy, loss of melanin, loss of adnexa.
52
Psoriasis: Anatomic sites (3).
Scalp.
Lumbosacral skin.
Extensor surfaces.
53
Psoriasis: Eponymous collections of neutrophils.
Microabscesses of Munro (stratum corneum).
Spongiform pustules of Kogoj (stratum spinosum).
54
Psoriasis: Appearance of granular layer.
Hypogranulosis underlying areas of parakeratosis.
55
Guttate psoriasis: Histology.
Less epidermal hyperplasia than in classic psoriasis.
56
Psoriatic arthritis:
A. Incidence.
B. Affected joints.
A. 15% of patients with psoriasis.
B. The DIP joints.
57
Psoriasis: Risk factor for severe disease.
AIDS.
58
Pityriasis rubra pilaris: Clinical appearance of fully developed disease.
Orange-red scaly plaques containing islands of normal skin.
59
