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Anatomic pathology > Skin > Flashcards

Flashcards in Skin Deck (352)
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30

Tumid lupus: Histology.

Superficial and deep infiltrate that spares epidermis; increased dermal mucin.

31

Lupus panniculitis: Histology.

Lobular panniculitis with hyaline fat necrosis.

32

Subacute and neonatal lupus: Histologic differences from discoid lupus (3).

Subacute and neonatal lupus show

− Prominent changes at the D-E junction.
− Less hyperkeratosis.
− Less inflammation.

33

Cutaneous lupus: Immunofluorescence.

Continuous granular deposition of IgG, IgM, and C3 at the dermoepidermal junction.

34

Cutaneous lupus: How to distinguish from polymorphous light eruption.

PLE: More papillary dermal edema than tumid lupus; no dermal mucin.

35

Cutaneous lupus: Lymphoma that may be in the differential diagnosis.

Subcutaneous panniculitis-like T-cell lymphoma must be distinguished from lupus panniculitis.

36

Lupus band test.

Direct immunofluorescence . . .

Discoid lupus: Positive in lesional skin only.

Systemic lupus: Positive in "normal" skin as well.

37

Anatomic location:

A. Heliotrope rash.
B. Gottron's papules.

A. Eyelids.

B. Knuckles, knees, elbows.

38

Dermatomyositis may resemble which type of cutaneous lupus histologically?

Subacute lupus.

39

Dermatomyositis: Age group.

Children.

Adults aged 45-65.

40

Dermatomyositis: Immunofluorescence.

C5b-C9 around blood vessels.

41

Dermatomyositis: Lupus-band test.

Negative.

42

Id reaction:

A. Synonym.
B. Leading cause.

A. Autoeczematization.

B. Remote dermatophytosis.

43

Spongiotic dermatitis: Changes that indicate chronicity (3).

Epidermal hyperplasia.

Hyperkeratosis.

Papillary dermal fibrosis.

44

Seborrheic dermatitis: Histology (2).

Mild spongiosis.

Parakeratosis at follicular ostia.

45

Pityriasis rosea: Histology (3).

Focal spongiosis.

Mounds of parakeratosis.

Extravasated erythrocytes.

46

Eosinophilic spongiosis: Differential diagnosis (4).

Allergic contact dermatitis.

Bullous pemphigoid, early.

Pemphigus, early.

Incontinentia pigmenti.

47

Incontinentia pigmenti:

A. Inheritance.
B. Epidemiology.

A. X-linked dominant.

B. Mostly females.

48

Histology of incontinentia pigmenti: Vesicular stage (3).

Eosinophilic spongiosis.

Single dyskeratotic keratinocytes.

Whorls of squamous cells.

49

Histology of incontinentia pigmenti: Verrucous stage (4).

Hyperkeratosis.

Papillomatosis.

Dyskeratosis.

Occasional eosinophils.

50

Incontinentia pigmenti: Gene and its location.

IKBKG (a.k.a. NEMO) on Xp28.

51

Histology of incontinentia pigmenti:

A. Hyperpigmented stage.
B. Hypopigmented stage (3).

A. Many melanophages in the upper dermis.

B. Epidermal atrophy, loss of melanin, loss of adnexa.

52

Psoriasis: Anatomic sites (3).

Scalp.

Lumbosacral skin.

Extensor surfaces.

53

Psoriasis: Eponymous collections of neutrophils.

Microabscesses of Munro (stratum corneum).

Spongiform pustules of Kogoj (stratum spinosum).

54

Psoriasis: Appearance of granular layer.

Hypogranulosis underlying areas of parakeratosis.

55

Guttate psoriasis: Histology.

Less epidermal hyperplasia than in classic psoriasis.

56

Psoriatic arthritis:

A. Incidence.
B. Affected joints.

A. 15% of patients with psoriasis.

B. The DIP joints.

57

Psoriasis: Risk factor for severe disease.

AIDS.

58

Pityriasis rubra pilaris: Clinical appearance of fully developed disease.

Orange-red scaly plaques containing islands of normal skin.

59

Pityriasis rubra pilaris:

A. Stratum corneum.
B. Follicles.

A. Horizontal and vertical alternation of orthokeratosis and parakeratosis.

B. Dilatation of infundibula; follicular plugging.