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Anatomic pathology > Skin > Flashcards

Flashcards in Skin Deck (352)
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150

Pustular drug eruption / acute exanthematous pustular dermatosis: Histology (3).

Subcorneal or intraepidermal pustules.

Spongiosis.

Dermal eosinophils.

151

Pemphigus: Clinical appearance of bullae.

Large, flaccid, fragile; positive Nikolsky's sign.

152

Pemphigus: Anatomic distribution.

Scalp, around eyes, sternum, mid-back, umbilicus, groin.

Oral lesions can occur.

153

Pemphigus vulgaris: Histology of early lesion.

Eosinophilic spongiosis.

154

Pemphigus vulgaris:

A. Location of split.
B. Contents of bulla.
C. Inflammatory infiltrate.

A. Suprabasal.

B. Acantholytic keratinocytes.

C. Superficial dermal, often with eosinophils.

155

Pemphigus vegetans.

Variant of pemphigus vulgaris in which lesions heal with verrucous vegetations.

156

IgA pemphigus:

A. Histology.
B. Antigen.

A. Resembles subcorneal pustular dermatosis.

B. Desmocollin.

157

Pemphigus vulgaris: Direct immunofluorescence.

Intercellular IgG.

158

Location of staining by direct immunofluorescence in

A. Pemphigus vulgaris.
B. Pemphigus vegetans.
C. Pemphigus foliaceus.

A,B. Deep epidermis.

C. Superficial epidermis.

159

Location of staining by direct immunofluorescence in pemphigus erythematosus.

Superficial epidermis, or along the DEJ as in SLE.

160

Paraneoplastic pemphigus: Characteristic histological feature.

Interface dermatitis.

161

Paraneoplastic pemphigus: Direct immunofluorescence (2).

Intercellular IgG.

Granular IgG or IgM at DEJ may also be seen.

162

Paraneoplastic pemphigus:

A. Antigen.
B. Substrate for indirect immunofluorescence.

A. Desmoplakin.

B. Rat bladder.

163

Antigens involved in

A. Pemphigus vulgaris.
B. Pemphigus erythematosus.

A. Desmoglein III.

B. Desmoglein I, desmoglein III.

164

Hailey-Hailey disease:

A. Inheritance.
B. Histologic features not found in pemphigus vulgaris.

A. Autosomal dominant.

B. Full-thickness acantholysis, sparing of follicular epithelium.

165

Grover's disease: Histologic distinction from pemphigus vulgaris.

Grover's disease:

Acantholysis is more focal.

A single specimen may show a combination of keratinocytic abnormalities.

166

Darier's disease:

A. Inheritance.
B. Clinical appearance.

A. Autosomal dominant.

B. Hyperkeratotic papules in a follicular distribution.

167

Darier's disease: Histologic features not found in pemphigus vulgaris.

Corps ronds, grains.

Both diseases show suprabasal acantholysis.

168

Staphylococcal scalded-skin syndrome: Location of split.

In the granular layer.

169

Bullous pemphigoid: Clinical appearance of bullae.

Large, tense; negative Nikolsky's sign.

170

Bullous pemphigoid:

A. Location of split.
B. Contents of bulla.

A. Subepidermal.

B. Many eosinophils (except in the cell-poor variant).

171

Bullous pemphigoid: Histology of early lesion (2).

Eosinophilic spongiosis.

Superficial dermal eosinophils.

172

Bullous pemphigoid: Immunofluorescence (2).

DIF: C3 and IgG at the DEJ.

Salt-split skin: Antibodies on the ceiling of the bulla.

173

Bullous pemphigoid: Involved antigens.

BP1 and BP2 in the hemidesmosomes.

174

Pemphigoid gestationis: Distinction from bullous pemphigoid (2).

May show more neutrophils and necrosis of basal cells.

Clinical correlation often required.

175

Epidermolysis bullosa acquisita: Clinical presentation.

Acral blisters that heal with scarring.

176

Epidermolysis bullosa acquisita: Distinction from bullous pemphigoid.

Salt-split skin: Antibodies on the floor of the bulla.

177

Porphyria cutanea tarda: Histologic features (3).

Subepidermal bulla with minimal inflammation.

Festooning extension of dermal papillae into the cavity of the bulla.

PAS-positive perivascular deposits in the papillary dermis.

178

Cicatricial pemphigoid: Clinical presentation.

Bullae that involve mucous membranes and heal with scarring.

179

Dermatitis herpetiformis: Anatomic sites (5).

Elbows, knees, back, buttocks, scalp.