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Anatomic pathology > Skin > Flashcards

Flashcards in Skin Deck (352)
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180

Dermatitis herpetiformis:

A. Location of split.
B. Contents of bullae.

A. Subepidermal.

B. Neutrophils, variable numbers of eosinophils.

181

Dermatitis herpetiformis: Histologic features in addition to bullae (2).

Neutrophils in tips of dermal papillae.

Superficial perivascular lymphocytes, neutrophils, eosinophils.

182

Dermatitis herpetiformis: Direct immunofluorescence.

Granular IgA in dermal papillae of normal skin and lesional skin.

183

Linear IgA dermatosis: Distinction from dermatitis herpetiformis.

Histology: May not be possible.

Direct immunofluorescence: Linear IgA at the DEJ.

184

Bullous systemic lupus erythematosus: Distinction from dermatitis herpetiformis.

Direct immunofluorescence: Granular IgG and C3 at the DEJ.

185

Eosinophilic pustular folliculitis:

A. Typical patients.
B. Histology.

A. Infants, immunocompromised.

B. Eosinophils in subcorneal pustules, in perifollicular infiltrates, and in spongiotic foci.

186

Majocchi's granuloma: Leading cause.

Trichophyton rubrum.

187

Follicular-occlusion triad.

Hidradenitis suppurativa.

Acne conglobata.

Perifolliculitis capitis abscedens et suffodiens.

188

Morphea / scleroderma: Early histology (2).

Perivascular and interstitial lymphocytes and plasma cells.

Thickening of bundles of collagen in the reticular dermis.

189

Morphea / scleroderma: Later histology (4).

Closely packed bundles of collagen.

Minimal inflammation.

Superficial displacement of eccrine glands.

Loss of other adnexa and of capillaries.

190

Morphea / scleroderma: Autoantibodies (2).

Morphea / CREST syndrome: Anticentromere.

Systemic sclerosis: Anti-Scl-70 (anti-topoisomerase).

191

Scleredema: Histology (2).

Collagen bundles are thickened but not hyalinized.

Hyaluronic acid fills widened spaces between collagen bundles.

192

Lichen sclerosus: Histology (4).

Epidermal atrophy.

Follicular plugging.

Basal vacuolar change.

Edema and homogenization of papillary dermis.

193

Radiation dermatitis: Vascular changes (2).

Superficial dermal telangiectasia.

Deep dermal blood vessels with fibrous thickening.

194

Nephrogenic systemic fibrosis:

A. Association.
B. Anatomic sites.

A. Renal disease.

B. Trunk and extremities.

195

Nephrogenic systemic fibrosis: Histology.

Thickened collagen bundles and CD34-positive spindled fibroblasts extending into subcutis and fascia.

196

Eosinophilic fasciitis: Histology.

Sclerosis and eosinophilic infiltrate of deep fascia.

197

Erythema nodosum: Anatomic location (2).

A. Acute: Extensor surfaces of legs; symmetrical.

B. Chronic: Legs; unilateral; recurrence at other sites.

198

Erythema nodosum: Associations (3).

Streptococcal pharyngitis.

Crohn's disease.

Sarcoidosis.

199

Erythema nodosum: Typical histology.

Granulomatous septal panniculitis that begins with lymphocytic and granulocytic inflammation.

200

Erythema nodosum: Ancillary test.

Special stains to exclude infectious (esp. tuberculous) panniculitis.

201

Subcutaneous fat necrosis of the newborn: Possible complications (2).

Hypercalcemia.

Thrombocytopenia.

202

Subcutaneous fat necrosis of the newborn: Histology.

Predominantly lobular inflammation.

Fat necrosis surrounded by macrophages and giant cells that contain a radial (or stellate) arrangement of needle-shaped lipid crystals.

203

Sclerema neonatorum: Distinction from subcutaneous fat necrosis of the newborn (2).

Sclerema neonatorum

Affects premature rather than full-term newborns.

Exhibits little or no inflammation.

204

Post-steroid panniculitis: Histology.

May resemble subcutaneous fat necrosis of the newborn; clinical history is essential.

205

Pancreatic fat necrosis: Distinguishing histologic features (2).

Ghostlike fat cells with thick borders.

No radially arranged lipid crystals.

206

Lipodystrophy: Histologic distinction from subcutaneous fat necrosis of the newborn.

Absence of needle-shaped crystals.

207

Erythema induratum: Histology.

Mixed lobular and septal panniculitis with vasculitis and zones of fat necrosis.

208

Epidermal-inclusion cyst:

A. Synonym.
B. Inherited cause of multiplicity.

A. Infundibular cyst.

B. Gardner's syndrome.

209

Steatocystoma multiplex: Inheritance.

Autosomal dominant.