Flashcards in Skin Deck (352)
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180
Dermatitis herpetiformis:
A. Location of split.
B. Contents of bullae.
A. Subepidermal.
B. Neutrophils, variable numbers of eosinophils.
181
Dermatitis herpetiformis: Histologic features in addition to bullae (2).
Neutrophils in tips of dermal papillae.
Superficial perivascular lymphocytes, neutrophils, eosinophils.
182
Dermatitis herpetiformis: Direct immunofluorescence.
Granular IgA in dermal papillae of normal skin and lesional skin.
183
Linear IgA dermatosis: Distinction from dermatitis herpetiformis.
Histology: May not be possible.
Direct immunofluorescence: Linear IgA at the DEJ.
184
Bullous systemic lupus erythematosus: Distinction from dermatitis herpetiformis.
Direct immunofluorescence: Granular IgG and C3 at the DEJ.
185
Eosinophilic pustular folliculitis:
A. Typical patients.
B. Histology.
A. Infants, immunocompromised.
B. Eosinophils in subcorneal pustules, in perifollicular infiltrates, and in spongiotic foci.
186
Majocchi's granuloma: Leading cause.
Trichophyton rubrum.
187
Follicular-occlusion triad.
Hidradenitis suppurativa.
Acne conglobata.
Perifolliculitis capitis abscedens et suffodiens.
188
Morphea / scleroderma: Early histology (2).
Perivascular and interstitial lymphocytes and plasma cells.
Thickening of bundles of collagen in the reticular dermis.
189
Morphea / scleroderma: Later histology (4).
Closely packed bundles of collagen.
Minimal inflammation.
Superficial displacement of eccrine glands.
Loss of other adnexa and of capillaries.
190
Morphea / scleroderma: Autoantibodies (2).
Morphea / CREST syndrome: Anticentromere.
Systemic sclerosis: Anti-Scl-70 (anti-topoisomerase).
191
Scleredema: Histology (2).
Collagen bundles are thickened but not hyalinized.
Hyaluronic acid fills widened spaces between collagen bundles.
192
Lichen sclerosus: Histology (4).
Epidermal atrophy.
Follicular plugging.
Basal vacuolar change.
Edema and homogenization of papillary dermis.
193
Radiation dermatitis: Vascular changes (2).
Superficial dermal telangiectasia.
Deep dermal blood vessels with fibrous thickening.
194
Nephrogenic systemic fibrosis:
A. Association.
B. Anatomic sites.
A. Renal disease.
B. Trunk and extremities.
195
Nephrogenic systemic fibrosis: Histology.
Thickened collagen bundles and CD34-positive spindled fibroblasts extending into subcutis and fascia.
196
Eosinophilic fasciitis: Histology.
Sclerosis and eosinophilic infiltrate of deep fascia.
197
Erythema nodosum: Anatomic location (2).
A. Acute: Extensor surfaces of legs; symmetrical.
B. Chronic: Legs; unilateral; recurrence at other sites.
198
Erythema nodosum: Associations (3).
Streptococcal pharyngitis.
Crohn's disease.
Sarcoidosis.
199
Erythema nodosum: Typical histology.
Granulomatous septal panniculitis that begins with lymphocytic and granulocytic inflammation.
200
Erythema nodosum: Ancillary test.
Special stains to exclude infectious (esp. tuberculous) panniculitis.
201
Subcutaneous fat necrosis of the newborn: Possible complications (2).
Hypercalcemia.
Thrombocytopenia.
202
Subcutaneous fat necrosis of the newborn: Histology.
Predominantly lobular inflammation.
Fat necrosis surrounded by macrophages and giant cells that contain a radial (or stellate) arrangement of needle-shaped lipid crystals.
203
Sclerema neonatorum: Distinction from subcutaneous fat necrosis of the newborn (2).
Sclerema neonatorum
Affects premature rather than full-term newborns.
Exhibits little or no inflammation.
204
Post-steroid panniculitis: Histology.
May resemble subcutaneous fat necrosis of the newborn; clinical history is essential.
205
Pancreatic fat necrosis: Distinguishing histologic features (2).
Ghostlike fat cells with thick borders.
No radially arranged lipid crystals.
206
Lipodystrophy: Histologic distinction from subcutaneous fat necrosis of the newborn.
Absence of needle-shaped crystals.
207
Erythema induratum: Histology.
Mixed lobular and septal panniculitis with vasculitis and zones of fat necrosis.
208
Epidermal-inclusion cyst:
A. Synonym.
B. Inherited cause of multiplicity.
A. Infundibular cyst.
B. Gardner's syndrome.
209
