Flashcards in Skin Deck (352)
Loading flashcards...
210
Seborrheic keratosis: Name of keratin-filled cysts.
Horn cysts (pseudo−horn cysts if they communicate with the stratum corneum).
211
Squamous eddies vs. keratin pearls.
Squamous eddies: Whorls of keratinocytes without central parakeratosis; seen in irritated seborrheic keratoses.
Keratin pearls: Central parakeratosis; seen in SCC.
212
Dermatosis papulosa nigra: Histology.
Same as that of seborrheic keratosis.
213
Clear-cell acanthoma:
A. Age group.
B. Anatomic site.
C. Clinical appearance.
A. Middle-aged and older.
B. Lower extremities.
C. Ulceration; oozing surface.
214
Clear-cell acanthoma: Histology (3).
Abrupt change to pale keratinocytes.
Elongated rete ridges with well-vascularized dermal papillae.
Neutrophils among keratinocytes and in the overlying parakeratosis.
215
Clear-cell acanthoma: Cause of clearing of cells.
Glycogen.
216
Verruca plana: Anatomic sites (2).
Face.
Dorsa of hands.
217
Verruca plana: Histology (3).
Blunt epidermal papillae.
Parakeratosis but minimal hyperkeratosis.
Keratinocytes with viral changes.
218
Actinic keratosis vs. SCC in situ.
AK: Alternating parakeratosis and orthokeratosis; orthokeratosis at the follicular ostia.
SCC: Confluent parakeratosis.
219
Bowenoid papulosis vs. SCC in situ.
Indistinguishable by histology.
Bowenoid papulosis occurs as papules on genitals.
220
Keratoacanthoma: Inflammatory feature.
Microabscesses.
221
Verrucous carcinoma: Histology.
Tunnels of parakeratosis extending deep into the neoplasm.
Bulbous expansion of rete pegs ("elephant's feet").
222
Marjolin's ulcer.
SCC arising on the edge of a longstanding ulcer or scar.
223
Trichoepithelioma: Inheritance of multiplicity.
Autosomal dominant.
224
Trichoepithelioma vs. BCC: Immunohistochemistry.
Trichoepithelioma: CD10 in stromal cells only.
BCC: CD10 in epithelial and stromal cells.
225
Giant solitary trichoepithelioma.
Several centimeters in size; found in deep dermis and subcutis.
226
Pilomatricoma:
A. Age group.
B. Anatomic sites (3).
A. Children, adolescents.
B. Face, neck, upper extremities.
227
Pilomatricoma: Clinical association of multiplicity.
Myotonic dystrophy.
228
Pilomatricoma: Significance of shadow cells.
They are matrical cells that are failing to form hair shafts.
229
Trichilemmoma:
A. Silhouette.
B. Histology of desmoplastic type.
A. Verruciform.
B. Irregular extensions of clear cells into sclerotic dermis simulate invasive carcinoma.
230
Cowden's disease:
A. Inheritance.
B. Affected organs.
A. Autosomal dominant.
B. Malignancies may occur in breast, gastrointestinal tract, thyroid gland, reproductive organs.
231
Syndrome of multiple basal-cell carcinomas:
A. Name.
B. Other abnormalities (2).
A. Basal-cell-nevus syndrome.
B. Palmar keratotic pits, jaw cysts.
232
Syringoma: Clinical appearance.
Multiple yellow, firm papules, 1-3 mm.
233
Syringoma: Histology (3).
Cords and nests of monomorphous epithelial cells.
Comma-shaped ducts lined by two layers of cells and filled with proteinaceous matter.
Densely fibrotic stroma.
234
Syringoma: Special stain.
PAS
− May highlight contents of ducts.
− May stain cells of clear-cell syringoma (glycogen).
235
Syringoma vs. trichoepithelioma.
Trichoepithelioma contains keratin-filled infundibulocystic structures rather than ducts.
236
Syringoma vs. microcystic adnexal carcinoma.
MAC is solitary, larger, and extends deep into the dermis.
237
Poroma: Cell types.
Poroid cells: Dark.
Cuticular: Pale and forming tubules.
238
Poroma: Stroma.
Richly vascular.
239
