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Anatomic pathology > Skin > Flashcards

Flashcards in Skin Deck (352)
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210

Seborrheic keratosis: Name of keratin-filled cysts.

Horn cysts (pseudo−horn cysts if they communicate with the stratum corneum).

211

Squamous eddies vs. keratin pearls.

Squamous eddies: Whorls of keratinocytes without central parakeratosis; seen in irritated seborrheic keratoses.

Keratin pearls: Central parakeratosis; seen in SCC.

212

Dermatosis papulosa nigra: Histology.

Same as that of seborrheic keratosis.

213

Clear-cell acanthoma:

A. Age group.
B. Anatomic site.
C. Clinical appearance.

A. Middle-aged and older.

B. Lower extremities.

C. Ulceration; oozing surface.

214

Clear-cell acanthoma: Histology (3).

Abrupt change to pale keratinocytes.

Elongated rete ridges with well-vascularized dermal papillae.

Neutrophils among keratinocytes and in the overlying parakeratosis.

215

Clear-cell acanthoma: Cause of clearing of cells.

Glycogen.

216

Verruca plana: Anatomic sites (2).

Face.

Dorsa of hands.

217

Verruca plana: Histology (3).

Blunt epidermal papillae.

Parakeratosis but minimal hyperkeratosis.

Keratinocytes with viral changes.

218

Actinic keratosis vs. SCC in situ.

AK: Alternating parakeratosis and orthokeratosis; orthokeratosis at the follicular ostia.

SCC: Confluent parakeratosis.

219

Bowenoid papulosis vs. SCC in situ.

Indistinguishable by histology.

Bowenoid papulosis occurs as papules on genitals.

220

Keratoacanthoma: Inflammatory feature.

Microabscesses.

221

Verrucous carcinoma: Histology.

Tunnels of parakeratosis extending deep into the neoplasm.

Bulbous expansion of rete pegs ("elephant's feet").

222

Marjolin's ulcer.

SCC arising on the edge of a longstanding ulcer or scar.

223

Trichoepithelioma: Inheritance of multiplicity.

Autosomal dominant.

224

Trichoepithelioma vs. BCC: Immunohistochemistry.

Trichoepithelioma: CD10 in stromal cells only.

BCC: CD10 in epithelial and stromal cells.

225

Giant solitary trichoepithelioma.

Several centimeters in size; found in deep dermis and subcutis.

226

Pilomatricoma:

A. Age group.
B. Anatomic sites (3).

A. Children, adolescents.

B. Face, neck, upper extremities.

227

Pilomatricoma: Clinical association of multiplicity.

Myotonic dystrophy.

228

Pilomatricoma: Significance of shadow cells.

They are matrical cells that are failing to form hair shafts.

229

Trichilemmoma:

A. Silhouette.
B. Histology of desmoplastic type.

A. Verruciform.

B. Irregular extensions of clear cells into sclerotic dermis simulate invasive carcinoma.

230

Cowden's disease:

A. Inheritance.
B. Affected organs.

A. Autosomal dominant.

B. Malignancies may occur in breast, gastrointestinal tract, thyroid gland, reproductive organs.

231

Syndrome of multiple basal-cell carcinomas:

A. Name.
B. Other abnormalities (2).

A. Basal-cell-nevus syndrome.

B. Palmar keratotic pits, jaw cysts.

232

Syringoma: Clinical appearance.

Multiple yellow, firm papules, 1-3 mm.

233

Syringoma: Histology (3).

Cords and nests of monomorphous epithelial cells.

Comma-shaped ducts lined by two layers of cells and filled with proteinaceous matter.

Densely fibrotic stroma.

234

Syringoma: Special stain.

PAS

− May highlight contents of ducts.
− May stain cells of clear-cell syringoma (glycogen).

235

Syringoma vs. trichoepithelioma.

Trichoepithelioma contains keratin-filled infundibulocystic structures rather than ducts.

236

Syringoma vs. microcystic adnexal carcinoma.

MAC is solitary, larger, and extends deep into the dermis.

237

Poroma: Cell types.

Poroid cells: Dark.

Cuticular: Pale and forming tubules.

238

Poroma: Stroma.

Richly vascular.

239

Painful tumors of the skin.

Blue-rubber-bleb nevus.
Eccrine spiradenoma.
Neuroma, neurilemmoma.
Glomus tumor.
Angiolipoma.
Leiomyoma.