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Anatomic pathology > Skin > Flashcards

Flashcards in Skin Deck (352)
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240

Spiradenoma:

A. Anatomic site.
B. Number.

A. Trunk and extremities.

B. Usually single but can be multiple.

241

Spiradenoma: Cell types (3).

Small, dark cells in the periphery of nodules.

Large, pale cells occupy the centers and line the tubules.

Lymphocytes.

242

Spiradenoma: Extracellular elements (2).

Hyaline basement-membrane-like matter.

Rich vascular supply.

243

Spiradenoma: Why painful?

Contains many unmyelinated axons.

244

Cylindroma: Type of differentiation.

Apocrine.

245

Cylindroma: Cell types.

Small, dark cells in the peripheral of nodules.

Large, pale cells occupy the centers and line the tubules.

246

Multiplicity of cylindromas:

A. Inheritance.
B. Gene and its location.

A. Autosomal dominant.

B. CYLD on 16q12.1.

247

Multiplicity of cylindromas may occur with multiplicity of what other tumor?

Trichoepithelioma.

248

Clear-cell hidradenoma:

A. Synonyms (3).
B. Basic architecture.

A. Nodular hidradenoma, solid-cystic hidradenoma, eccrine acrospiroma.

B. Nodule consisting of cellular lobules and cystic spaces.

249

Clear-cell hidradenoma: Cell types (2).

Clear cells make up the bulk of the tumor.

Cuboidal or columnar cells with decapitation secretion line the tubules.

250

Syringocystadenoma papilliferum:

A. Anatomic sites.
B. Associated proliferation.

A. Scalp, face.

B. Naevus sebaceus.

251

Syringocystadenoma papilliferum: Cells that line the papillae.

Luminal row: Columnar cells with occasional decapitation secretion.

Deeper row: Cuboidal cells.

252

Syringocystadenoma papilliferum: Stroma.

Full of plasma cells.

253

Syringocystadenoma papilliferum vs. hidradenoma papilliferum (2).

Hidradenoma papilliferum:

− No connection to the skin's surface.
− Papillae have one layer of cells (apocrine).

254

Syringocystadenoma papilliferum vs. tubular apocrine adenoma.

Tubular apocrine adenoma: No connection to skin's surface.

255

Microcystic adnexal carcinoma: Anatomic sites (4).

Upper lip (#1).

Chin, nasolabial fold, cheek.

256

Microcystic adnexal carcinoma: Histology.

Bland-appearing ductal structures, with or without keratin-filled cysts, infiltrate deep dermis, subcutis, and muscle, getting smaller toward the base.

Usually no connection to the surface.

257

Microcystic adnexal carcinoma: Clue to malignancy.

Perineural invasion.

258

Microcystic adnexal carcinoma: Behavior.

Locally aggressive but rarely metastasizes.

259

Naevus sebaceus: Age group.

Present at birth.

260

Naevus sebaceus:

A. Clinical development.
B. Histologic development.

A. Plaque-like in infancy, linear in childhood, verrucous and nodular at puberty.

B. Sebaceous glands are large at birth and in puberty, small in childhood.

261

Naevus sebaceus: Non-sebaceous histology (3).

Papillomatosis.

Follicular germs resembling BCC.

Apocrine glands deep in the dermis.

262

Naevus sebaceus: Tumors that can arise in it (3).

Benign: Trichoblastoma, syringocystadenoma papilliferum.

Malignant: BCC.

263

Naevus sebaceus vs. epidermal nevus.

Epidermal nevus lacks sebaceous lobules.

264

Sebaceous adenoma: Histology.

Increased basaloid cells at periphery of sebaceous lobules.

Mitotic figures may be present, but no nuclear atypia.

265

Sebaceous adenoma, rippled-pattern: Histology.

Parallel rows of monomorphous, fusiform cells that resemble Verocay bodies.

Sebaceous cells and ducts also present.

266

Sebaceous adenoma: Ancillary study.

IHC for loss of mismatch-repair proteins (MSH2/MLH1) should be considered.

267

Sebaceous carcinoma: Anatomic site.

Eyelid, particularly the meibomian glands and the gland of Zeis.

268

Sebaceous carcinoma: Histology (2).

Irregular lobules consisting of pleomorphic basaloid cells, sometimes with a few sebaceous cells in the center.

Eyelid: Pagetoid spread into conjunctiva or epidermis.

269

Sebaceous carcinoma: Relationship to SCC (2).

Sebaceous carcinoma can

− Arise in a site of SCC.
− Contain SCC-like squamoid areas.