Flashcards in Skin Deck (352)
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240
Spiradenoma:
A. Anatomic site.
B. Number.
A. Trunk and extremities.
B. Usually single but can be multiple.
241
Spiradenoma: Cell types (3).
Small, dark cells in the periphery of nodules.
Large, pale cells occupy the centers and line the tubules.
Lymphocytes.
242
Spiradenoma: Extracellular elements (2).
Hyaline basement-membrane-like matter.
Rich vascular supply.
243
Spiradenoma: Why painful?
Contains many unmyelinated axons.
244
Cylindroma: Type of differentiation.
Apocrine.
245
Cylindroma: Cell types.
Small, dark cells in the peripheral of nodules.
Large, pale cells occupy the centers and line the tubules.
246
Multiplicity of cylindromas:
A. Inheritance.
B. Gene and its location.
A. Autosomal dominant.
B. CYLD on 16q12.1.
247
Multiplicity of cylindromas may occur with multiplicity of what other tumor?
Trichoepithelioma.
248
Clear-cell hidradenoma:
A. Synonyms (3).
B. Basic architecture.
A. Nodular hidradenoma, solid-cystic hidradenoma, eccrine acrospiroma.
B. Nodule consisting of cellular lobules and cystic spaces.
249
Clear-cell hidradenoma: Cell types (2).
Clear cells make up the bulk of the tumor.
Cuboidal or columnar cells with decapitation secretion line the tubules.
250
Syringocystadenoma papilliferum:
A. Anatomic sites.
B. Associated proliferation.
A. Scalp, face.
B. Naevus sebaceus.
251
Syringocystadenoma papilliferum: Cells that line the papillae.
Luminal row: Columnar cells with occasional decapitation secretion.
Deeper row: Cuboidal cells.
252
Syringocystadenoma papilliferum: Stroma.
Full of plasma cells.
253
Syringocystadenoma papilliferum vs. hidradenoma papilliferum (2).
Hidradenoma papilliferum:
− No connection to the skin's surface.
− Papillae have one layer of cells (apocrine).
254
Syringocystadenoma papilliferum vs. tubular apocrine adenoma.
Tubular apocrine adenoma: No connection to skin's surface.
255
Microcystic adnexal carcinoma: Anatomic sites (4).
Upper lip (#1).
Chin, nasolabial fold, cheek.
256
Microcystic adnexal carcinoma: Histology.
Bland-appearing ductal structures, with or without keratin-filled cysts, infiltrate deep dermis, subcutis, and muscle, getting smaller toward the base.
Usually no connection to the surface.
257
Microcystic adnexal carcinoma: Clue to malignancy.
Perineural invasion.
258
Microcystic adnexal carcinoma: Behavior.
Locally aggressive but rarely metastasizes.
259
Naevus sebaceus: Age group.
Present at birth.
260
Naevus sebaceus:
A. Clinical development.
B. Histologic development.
A. Plaque-like in infancy, linear in childhood, verrucous and nodular at puberty.
B. Sebaceous glands are large at birth and in puberty, small in childhood.
261
Naevus sebaceus: Non-sebaceous histology (3).
Papillomatosis.
Follicular germs resembling BCC.
Apocrine glands deep in the dermis.
262
Naevus sebaceus: Tumors that can arise in it (3).
Benign: Trichoblastoma, syringocystadenoma papilliferum.
Malignant: BCC.
263
Naevus sebaceus vs. epidermal nevus.
Epidermal nevus lacks sebaceous lobules.
264
Sebaceous adenoma: Histology.
Increased basaloid cells at periphery of sebaceous lobules.
Mitotic figures may be present, but no nuclear atypia.
265
Sebaceous adenoma, rippled-pattern: Histology.
Parallel rows of monomorphous, fusiform cells that resemble Verocay bodies.
Sebaceous cells and ducts also present.
266
Sebaceous adenoma: Ancillary study.
IHC for loss of mismatch-repair proteins (MSH2/MLH1) should be considered.
267
Sebaceous carcinoma: Anatomic site.
Eyelid, particularly the meibomian glands and the gland of Zeis.
268
Sebaceous carcinoma: Histology (2).
Irregular lobules consisting of pleomorphic basaloid cells, sometimes with a few sebaceous cells in the center.
Eyelid: Pagetoid spread into conjunctiva or epidermis.
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