Sz Flashcards
(43 cards)
Schizophrenia symptoms can be divided into
Positive
Negative
Positive schizophrenia symptoms represent
An excess of normal function
Delusions, hallucinations, inappropriate affect are all examples of
Positive symptoms
Negative schizophrenia symptoms represent
A loss of normal function
What is affective flattening?
Reduction/absence of emotional expression
schizophrenia means
Splitting of psychic functions
How much of the population does schizophrenia affect?
1%
What is the schizophrenia concordance rate for Mz twins?
45%
What is the schizophrenia concordance rate for Dz twins?
10%
< 100% concordance rates indicate…
There must be other factors playing a role
3 environmental factors that could trigger schizophrenia?
- Infections
- Autoimmune reactions
- Stress
What is the current view on how schizophrenia develops?
People inherit a potential
May or may not be triggered
What genes cause schizophrenia?
No single gene
They act in combination
Bullying is a risk factor for Sz. This may be mediated by
Severity
Frequency
Dopamine is packaged into
Vesicles
L-Dopa –>
Dopamine
Chlorpromazine
Is an agonist/antagonist
Antagonist
What does Chlorpromazine do?
Binds + blocks post-synaptic dopamine receptors
Stops the dopamine working
How does Chlorpromazine stop the dopamine working?
It can’t get to the post-synaptic receptors
What is an antagonist?
A drug that binds to a receptor but has no effect (blocks it)
How does reserpine work?
Depletes the dopaminergic vesicles
Why is reserpine no longer used in Sz treatment?
Dangerous blood pressure decline
2 similarities between Chlorpromazine and Reserpine?
- Both take 2/3 weeks to work
2. PD-like symptoms start to emerge
After using Chlorpromazine or Reserpine, PD-like symptoms began to emerge. This suggested that
Drugs/Parkinson’s were acting through the same mechanism
