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TABLETS Flashcards

1
Q

are solid pharmaceutical dosage form containing drug substances usually prepared by molding or compression with the aid of suitable excipients

A

TABLETS

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2
Q

tablets may vary in ____, ____, ____, ____, ____, ____, and ____ characteristics and in other aspects, depending on their intended use and method of manufacture

7

A

size
shape
weight
hardness
thickness
disintegration
dissolution

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3
Q
  • uncoated tablet manufactures by compression
  • with sufficient pressure forcing the powders or granules to make the desired shape
  • contained no special coating
A

COMPRESSED TABLETS

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4
Q

fillers designed to make up the desired bulk, flow properties and compression characteristics

EXAMPLES: lactose, mannitol starch, dibasic calcium phosphate, sorbi

A

DILUENT OR FILLERS

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5
Q

used to cause adhesion of powder particles in tablet granulations

acacia, carboxymethylcellulose, gelatin, pregelatinized starch

A

HINDERS OR ADHESIVES

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6
Q

promote disruption of solid mass into smaller particles

carboxymethylcellulose, starch, microcrytalline cellulose

A

DISINTEGRANTS

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7
Q

to improve the flow of the powdered mixture

colloidal silica, cornstarch, talc

A

GLIDANTS

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8
Q

prevent tablet ingredients from sitcking to punches and dies during production

magnesium stearate

A

ANTI-ADHERENT

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9
Q

reduce friction during tablet compression

Ca, Mg, Zn stearate, mineral oil, stearic acid

A

LUBRICANT

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10
Q

what type of excipient is the dibasic calcium phosphate (Ditab)?

A

DIRECT COMPRESSION EXCIPIENT

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11
Q

FD&C lakes are used as

A

COLORANT

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12
Q

colorant used in tablets

A

FD&C lake

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13
Q

flavoring agent and sweetening agent is added in ____ and ____ tablet

A

CHEWABLE
BUCCAL

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14
Q

substances capable of holding quantities of fluids in an apparently dry state

fused silica, bentonite, kaolin, magnesium carbonate, microcrystalline

A

ADSORBENTS

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15
Q

tablet coating that contains liquid glucose, sucrose

A

SUGAR-COATING AGENTS

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16
Q

sugar-coating agents

A

LIQUID GLUCOSE
SUCROSE

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17
Q

tablet coating that contains methylcellulose, ethylcellulose, hydroxy-ethyl cellulose, hydroxy propyl cellulose

A

FILM-COATING AGENTS

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18
Q

tablet coating that contains cellulose acetate phthalate, shellac (35% in alcohol, “pharmaceutical glaze”)

A

ENTERIC-COATING AGENTS

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19
Q

% of shellac in alcohol

A

35%

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20
Q

35% in alcohol
pharmaceutical glaze

A

SHELLAC

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21
Q

shellac is also known as

A

PHARMACEUTICAL GLAZE

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22
Q

prepare by subjecting the fill material to more than a single compression

A

MULTI-LAYERED TABLET

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23
Q
  • protects the enclosed drug from the environment and provides a barrier to objectionable taste or odor
  • DISADVANTAGE: 50% larger and heavier than the original uncoated tablet
A

SUGAR-COATED TABLET

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24
Q
  • coated with a thin layer of polymer capable of forming a skin-like film over the tablet
  • ADVANTAGES: more durable, less bulky, less time-consuming to apply
A

FILM-COATED TABLET

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25
**capsule shaped** compressed tablet. **more tamper-evident** than unsealed capsules
GELATIN-COATED TABLET
26
has a **delayed release** feature and **disintegrates in the small intestine**
ENTERIC-COATED TABLET
27
**where** does the **enteric-coated tablet** disintegrates?
SMALL INTESTINE
28
gelatin-coated tablet is **more tamper-evident** than
UNSEALED CAPSULES
29
designed to disintegrate and release their medication with **no specific rate-controlling features**
IMMEDIATE RELEASE TABLET
30
designed to release their medication in a **predetermined manner** over an **extended period**
EXTENDED RELEASE TABLET
31
**dissolves** in the **buccal pouch** and it **erode slowly**
BUCCAL TABLET
32
* dissolves **beneath the tounge** and it dissolved **promptly** and produce **rapid effect** * used in **sudden pain** (chest pain)
SUBLINGUAL TABLET
33
* are especially useful for administration of **large tablets** to **children** and **adults** who have **difficulty in swallowing** * **do not contain disintegrants** * commonly used excipient: **mannitol**
CHEWABLE TABLET
34
commonly used **excipient** in **chewable tablets**
MANNITOL
35
common **sweetener** used in **chewable tablet**
MANNITOL
36
common **sweetener** used in **sugar-free chewable tablets**
XYLITOL
37
* **disc-shaped**, solid dosage forms containing medicinal agent and generally a flavoring substance in a **hard candy** or sugar base * they are intended to be **dissolved slowly in the oral cavity** for **localized effects** * made by compression or molding * **candy type** preparation
LOZENGES
38
another term for **lozenges**
TROCHES
39
**lozenges** in a **gummy type** preparation
PASTILLES
40
* disintegrating or dissolving in the mouth within **1 minute**, some within **10 secs** * designed for children & elderly who has **difficulty in swallowing** * **liquefy in tounge** and patient swallows
RAPID RELEASE TABLET
41
* also called **vaginal inserts** * uncoated, **bullet-shaped** or **ovoid tablets** inserted into the **vagina** for local effects * made by compression * a **plastic inserter** usually accompany the product
VAGINAL TABLET
42
what usually **accompanies** vaginal inserts/tablets
PLASTIC INSERTER
43
* a small tablet that is prepared for **insertion under the skin** by giving a small surgical cut into the skin which is stitched after the insertion of tablets * the tablet must be **sterile** * **do not contain excipients** * contraceptive tablets
IMPLANTS
44
prepared by compressing **granular effervescent salt** and **releases carbon dioxide** when in contact with water
EFFERVESCENT TABLET
45
* small, usually cylindrical molded or compressed tablet containing **small amount of usually potent drugs** * tablet is **soft** and **soluble** * has **rapid effect** * combination of **sucrose + lactose** * **inserted in a capsule** or **dissolved in liquid** to provide accurate amount of potent drug substances * prepared by **molding method**
MOLDED TABLETS / TABLET TRITURATES
46
molded tablet is also known as
TABLET TRITURATES
47
Molded tablets / tablet triturates are a combination of
sucrose + lactose
48
**sweetener** used in molded tablet / tablet triturate
SUCROSE
49
**diluent** used in molded tablet / tablet triturate
LACTOSE
50
commonly used **diluent** in molded tabs | 2
SUCROSE LACTOSE
51
* used by **doctors** in **extemporaneous preparation** of **parenteral solutions** * tablets are dissolved in **suitable vehicle**, sterility is attained then injected * **not used anymore** because of sterility problem
HYPODERMIC TABLETS
52
* contains **large amount** of **highly potent drug substances**, pharmacists could rapidly obtain premeasured amounts of compounding multiple dosage units * no longer available
DISPENSING TABLETS
53
**dispensing tablets** are also known as
COMPOUNDING TABLETS
54
added in containers that is used to **absorb moisture**
DESSICANT PACKET
55
* a **raspberry sugar-based lozenge on a stick** containing **fentanyl citrate** * **Actiq** is the **first product designed** to aid in controlling breakthrough pain in **cancer patients** * immediate relief -- its effect lasts for **15 mins**
LOLLIPOPS
56
lollipops contains
FENTANYL CITRATE
57
# lollipop the **first product designed** to aid in controlling breakthrough pain in **cancer patients**
ACTIQ
58
the effect of lollipops last for how many mins
15 mins
59
**first manufacture** who produced lollipops
CEPHANOL
60
* small, solid particles of **uniform shape** sometimes called **beads** * may be given **orally** or **parenterally** * **physical separation of incompatible substances** * placed inside hard gelatin capsule
PELLETS
61
pellets are sometimes called as
BEADS
62
* small, round, solid dosage forms containing a medicinal agent intended to be administered orally * prepared by a **wet massing** and **molding technique** * excipients are selected based on their **ability to produce a firm** and **plastic mass** * **liquid excipients** are added to **bind** and **provide plasticity** to the mass, which is formed by **kneading** * the **firmness** and **plasticity** are required for the mass to be worked and retain the produced shape
PILLS
63
pills are prepared by
WET MASSING MOLDING TECHNIQUE
64
# pills are added to **bind** and **provide plasticity** to the mass, which is formed by **kneading**
LIQUID EXCIPIENTS
65
# PILLS required for the **mass to be worked** and **retain the produced shape** | 2
FIRMNESS PLASTICITY
66
allows the tablets to be **easily break into two or more parts**
SCORE, GROOVE
67
add the **necessary bulk** to a formulation to prepare tablets of the desired size
DILUENT OR FILLERS
68
promote **adhesion** of the particles of the formulation, allowing granulation to be prepared and maintaining the integrity of the final tablet
BINDERS OR ADHESIVES
69
**promote breakup** of the tablets after administration to smaller particles for ready drug availabiltiy
DISINTEGRANTS
70
inner tablet being the
CORE
71
outer tablet being the
SHELL
72
the coating of sugar coated tablets are | 2
water soluble quickly dissolves
73
a tablet's **durability** may be determined by
FRIABILATOR
74
**widely employed method** for the production of compressed tablets
WET GRANULATION
75
% of **starch** that is **usually suitable**
5% - 10%
76
% of **starch** that may be used to **promote more rapid tablet disintegration**
20%
77
# METHOD * the powder mixture is **compacted in large pieces** and **subsequently broken down** or **sized** **into granules** * either **active ingredient** or the **diluent** **must have cohesive properties**
DRY GRANULATION METHOD
78
may be used to **increase the density** of a powder
POWDER COMPACTORS
79
about 70% as sweet as sucrose
MANNITOL
80
a **waterproofing** substance
SHELLAC
81
method used in **hard** tablets
COMPRESSION
82
method used in **soft** tablets
MOLDING
83
prevents friction
LUBRICANT
84
large, usually elongated tablets intended for administration to **large animals**
BOLUS TABLETS
85
# PATIENT COUNSELING what should not be done after taking a chewable tablet
do not drink water immediately
86
# PATIENT COUNSELING Buccal tablets
30mins - 1hr after taking the tablet saka uminom ng water rotate/alternate sides of the cheek
87
# PATIENT COUNSELING ORALLY DISINTEGRATING TABLETS
do not take water immediately
88
# PATIENT COUNSELING LOZENGES
bawal kagatin

DOSAGE (19 decks)

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