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Flashcards in Topical Medications Deck (57)
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1

will cause increased pain and stinging when used on hand eczema due to the alcohol base of the gel

glucocorticoid gel

2

may cause folliculitis secondary to its occlusive properties

treating a moist lesion with an ointment

3

determines the rate and strength at which the active ingredient is absorbed through the skin

vehicle (base)

4

In general, what type of preparations are used for acute and chronic inflammations?

acute-aqueous drying preparations. chronic-greasier, lubricating compounds

5

A progressive decrease in clinical response due to repetitive application of a drug. Body becomes tolerant to therapeutic effect

tachyphylaxis

6

Aid in absorbing moisture, decrease friction and help cover wide areas easily. Primarily used in intertriginous areas

powders

7

lotions with very minimal oil or solid content, but with active ingredients. (e.g. Visine)

solutions

8

Alcoholic or hydroalcoholic solutions (may cause pain and irritation on erosions and abrasions)

tinctures

9

Consist of suspension of powder in water considered least potent topical therapies. Considered drying and useful in hairy areas and to treat large areas

lotions

10

oils are dispersed in the water usually with surfactant (to make them miscible). leave a slight residue as the water evaporates

emollient lotions

11

Semisolid emulsions of oil in water about equal proportion. Penetrates the stratum corneum of the skin well

Creams

12

Downside to creams

cause more adverse reactions because of preservatives

13

Consist of water droplets suspended in the continuous phase of oil (mineral oil) or of inert bases such as petrolatum (Vaseline).

ointments

14

Why are ointments generally the most potent vehicle?

due to their occlusive effect

15

Transparent semisolid emulsion that liquefies on contact with skin, drying as a thin, greaseless, non-occlusive film. Consist of a hydrophilic base with water or acetone

gels

16

Type of lesions gels are useful for

exudative inflammation (poison ivy), scalp and hair-bearing areas, acne

17

Average total body application for different vehicles

30-60 grams for adults

18

Therapy of choice for most inflammatory conditions such as pruritic eruptions (dermatitis), hyperplastic disorders (psoriasis), infiltrative disorders (sarcoid)

topical glucocorticoids

19

Strongest steroid known to cause suppression of hypothalamic-pituitary system with only 2g

Clobetasol

20

Mildest of steroids that can be used for infants

hydrocortisone

21

Amount of potent steroid likely to cause hypothalamic-pituitary system suppression

>50-100g weekly for longer than 2 wks

22

local adverse effects of topical corticosteroids that are reversible and irreversible

reversible-atrophy and telangiectasias. irreversible- striea distensae

23

Anatomic regions significantly more permeable to topical steroids

thin epidermis (genitals, cheek, forehead)

24

Condition that increases absorption of topical steroids

increased skin hydration

25

Super-potent topical corticosteroid packaged as a cream vehicle

betamethasone dipropionate

26

used for severe dermatoses over non facial/nonintertiginous areas. Useful over the palms and soles.

super potent (class I) topical corticosteroid

27

appropriate for mild to moderate nonfacial/nonintertriginous dermatoses

intermediate to potent (class II-III) topical corticosteroids

28

should be considered when large areas are treated because of the likelihood of systemic absorption

mild-intermediate (class IV-V) topical corticosteroids

29

should be managed with mild strength topical steroids (class VI-VII)

eyelid and genital dermatoses

30

How much should you dispense for a dermatitis of the finger?

15 grams