Skin Manifestations of Systemic Disorders Flashcards Preview

Dermatology (also gross but true) > Skin Manifestations of Systemic Disorders > Flashcards

Flashcards in Skin Manifestations of Systemic Disorders Deck (34)
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1

Dermatologic manifestations seen with Crohn's and ulcerative colitis

pyoderma gangrenosum and erythema nodosum

2

chronic and severely debilitating ulcerative skin disease. Painful hemorrhagic pustule surrounded by erythematous halo

pyoderma gangrenosum

3

Most common sites for pyoderma gangrenosum

lower extremities, butt, abdomen

4

Describe lesion that characterizes pyoderma gangrenosum

Irregular, boggy, blue-red ulcers with undetermined borders surrounding a purulent necrotic base

5

What can you use for high dose systemic corticosteroid treatment of pyoderma gangrenosum?

oral or IV prednisolone 1-2g per day. Can add intralesional triamcinolone

6

Systemic immunosuppression that can be effective in treating pyoderma gangrenosum

sulfasalazine, cyclosporine, infliximab

7

Skin condition associated with DM, obesity, internal malignancy (esp. GI)

acanthosis nigricans

8

Most common sites for acanthosis nigricans

axilla, neck, groin, antecubital fossae

9

Cutaneous disorder often associated with DM. Lesions are distinctive, sharply dircumscribed, multicolored (red, yellow, brown) plaques occurring on the anterior and lateral surfaces of the lower legs

Necrobiosis Lipoidica (NL), Diabeticorum

10

Treatment of Necrobiosis Lipoidica (NL), Diabeticorum

Refer. Topical steroids for ulcerations. May need excision and grafting

11

Self limiting, chronic dermatosis more common in older women characterized by smooth, shiny firm colored papules/plaques that are annular w/central depression

granuloma annular

12

Most common sites for granuloma annular

dorsum of hands/feet, extremities, and trunk

13

Percentage of patients with granuloma annular whose symptoms disappear in 2 yrs w/out treatment

75%. Can be treated w/potent topical and intralesional steroids

14

Usually occurs in areas of increased moisture at the site of infection, DM, or altered systemic immunity. Presents with erythema, tenderness, plaques, possible pruritis

intertrigo

15

Treatment for intertrigo if found to be caused by fungus

Dry area, wash with benzoyl peroxide or powder with miconazole daily

16

A candida infection occuring on the mucosa of the upper aerodigestive tract. Associated with HIV, DM, immunosuppression

thrush

17

Treatment for thrush in a patient with a competant immune system

azoles/imidazoles

18

Treatment for thrush in a patient who is immunocompromised

oral therapy-fluconazole 2-3 wks

19

chronic, indolent skin disease associated with Lupus that is characterized by sharply marginated, scaly, atrophic, red (discoid) plaques primarily on face

chronic cutaneous (discoid)

20

Treatment for chronic cutaneous (discoid) lupus

local corticosteroids, intralesional triamcinolone, and hydroxychloroquine

21

Occurs in women 15-40 and is characterized by polycyclic scaly plaques in sun exposed areas. also associated with lupus

subacute cutaneous (cutaneous lupus erytheratosus)

22

Condition characterized by butterfly” facial erythema which is nonscarring, Photosensitivity, Oral ulcers

lupus

23

treatment for lupus and cutaneous lupus erytheratosus

antimalarials and immunosuppression

24

Systemic disorder characterized by violaceous (heliotrope) inflammatory changes of the eyelids and periorbital area, photosensitivity, Gattron's papules

dermatomysitis

25

violaceous papules over knuckle prominences

Gattrons papules

26

Treatement for dermatomyositis

steroids and methotrexate

27

Name the components of CREST syndrome

calcinosis, Raynaud's, esophageal dysmotility, sclerodactyly, telangiectasia

28

Generalized sclerosis with internal organ involvement (heart, lungs, GI, kidney

progressive systemic sclerosis

29

Lipid deposits in skin and tendons. Yellow-brown, pinkish, or orange macules/papules due to accumulations of macrophages containing droplets of lipids

xanthomas

30

Conditions associated with xanthomas

hyperlipidemia, biliary cirrhosis, DM, CRF