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Flashcards in Desquamation Disorders Deck (31)
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1

characteristic erythematous iris-shped papules and vesicobullous lesions involving the extremities (especially the palms and soles) and the mucus membranes

erythema multiforme

2

What are the major differences between EM minor and EM major?

EM minor is often due to HSV and has few systemic sx, whereas EM major is often due to meds and has systemic sx

3

What do the following medications have in common: bactrim, dapsone, anti-epilectics, PCN, cephalosporins, and allopurionol?

frequent offenders to cause erythema multiforme

4

drug induced or idiopathic rxn patterns characterized by skin tenderness and erythema followed by cutaneous and mucosal exfoliation. potentially life threatening

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

5

considered a maximal variant of Erythema Multiforme Major

Steven's Johnsons

6

Considered a maximal variant of Steven's Johnsons

toxic epidermal necrolysis

7

Most common age of presentation for SJS and TEN

> 40yrs

8

How long after drug exposure might SJS or TEN occur?

1-3 weeks

9

Conditions that are risk factors for SJS or TEN

Lupus, HIV, HLS-B12

10

Treatment for SJS/TEN

Cessation of causative drug. ICU, fluids, IVIG (halts progression). erythromycin ointment for eye lesions

11

Medication that is commonly associated with a drug rash

Bactrim (Septra)

12

Treatment for drug rash

benadryl, steroids, avoid sweating

13

What do the following have in common: petechiae, subungal splinter hemorrhages, Osler's nodes, Janeway lesions, roth spots.

peripheral lesions of bacterial endocarditis

14

exudative lesions in the retina

roth spots

15

Small, non-blanching, reddish-brown macules on extremities, upper chest, mucus membranes. Occur in crops

petechial lesion

16

Establish the diagnosis of bacterial endocarditis

blood cultures (3 sets 1hr before abx)

17

Patient presents 1-2 wks after tick bite with fever > 102, chills, weakness, headache and photophobia. Indirect fluorescent antibody is positive

RMSF

18

What day of fever does a red macular rash of RMSF that evolves to petechiae usually show up?

2nd-6th day

19

Common areas involved in RMSF rash

palms and soles

20

What do you need to rule out when diagnosing RMSF with blood cultures and CSF?

meningoccemia

21

How is meningococcemia transmitted?

droplets

22

pain in the hamstrings upon extension of the knee with the hip at a 90 degree flexion

Kernig sign

23

flexion of the knee in response to flexion of the neck.

brudzinski

24

Patient presents with nuchal and back rigidity, high fever, chills, HA. Kernig and Brudzinkski are positive

meningococcemia

25

Common locations of the pink 2mm-10mm macule/papule rash of meningococcemia

pressure points and lower extremities

26

Important complication of meningococcemia typically present in toxic patients with ecchymotic skin lesions

DIC

27

fibrin degradation product, present when coagulation system has been activated

D-Dimer

28

What conditions does D-Dimer aid in diagnosing?

DIC and DVT

29

Caused by Neisseria gonorrhoeae. Early phase consists of tenosynovitis, arthralgias, dermatitis, and peripheral skin lesions.

Gonococcemia

30

Describe the classic skin lesions of gonococcemia

acral hemorrhagic pustules