Flashcards in Desquamation Disorders Deck (31)
characteristic erythematous iris-shped papules and vesicobullous lesions involving the extremities (especially the palms and soles) and the mucus membranes
What are the major differences between EM minor and EM major?
EM minor is often due to HSV and has few systemic sx, whereas EM major is often due to meds and has systemic sx
What do the following medications have in common: bactrim, dapsone, anti-epilectics, PCN, cephalosporins, and allopurionol?
frequent offenders to cause erythema multiforme
drug induced or idiopathic rxn patterns characterized by skin tenderness and erythema followed by cutaneous and mucosal exfoliation. potentially life threatening
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
considered a maximal variant of Erythema Multiforme Major
Considered a maximal variant of Steven's Johnsons
toxic epidermal necrolysis
Most common age of presentation for SJS and TEN
How long after drug exposure might SJS or TEN occur?
Conditions that are risk factors for SJS or TEN
Lupus, HIV, HLS-B12
Treatment for SJS/TEN
Cessation of causative drug. ICU, fluids, IVIG (halts progression). erythromycin ointment for eye lesions
Medication that is commonly associated with a drug rash
Treatment for drug rash
benadryl, steroids, avoid sweating
What do the following have in common: petechiae, subungal splinter hemorrhages, Osler's nodes, Janeway lesions, roth spots.
peripheral lesions of bacterial endocarditis
exudative lesions in the retina
Small, non-blanching, reddish-brown macules on extremities, upper chest, mucus membranes. Occur in crops
Establish the diagnosis of bacterial endocarditis
blood cultures (3 sets 1hr before abx)
Patient presents 1-2 wks after tick bite with fever > 102, chills, weakness, headache and photophobia. Indirect fluorescent antibody is positive
What day of fever does a red macular rash of RMSF that evolves to petechiae usually show up?
Common areas involved in RMSF rash
palms and soles
What do you need to rule out when diagnosing RMSF with blood cultures and CSF?
How is meningococcemia transmitted?
pain in the hamstrings upon extension of the knee with the hip at a 90 degree flexion
flexion of the knee in response to flexion of the neck.
Patient presents with nuchal and back rigidity, high fever, chills, HA. Kernig and Brudzinkski are positive
Common locations of the pink 2mm-10mm macule/papule rash of meningococcemia
pressure points and lower extremities
Important complication of meningococcemia typically present in toxic patients with ecchymotic skin lesions
fibrin degradation product, present when coagulation system has been activated
What conditions does D-Dimer aid in diagnosing?
DIC and DVT
Caused by Neisseria gonorrhoeae. Early phase consists of tenosynovitis, arthralgias, dermatitis, and peripheral skin lesions.