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Jason's Renal Block > Transplantation > Flashcards

Flashcards in Transplantation Deck (24)
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0

isograft? allograft? xenograft?

iso: identical twin
allograft: same species
xenograft: different species

1

ABO just in blood?

nope other systems as well, so try to match for transplant as well

2

1st of 2nd graft more tolerated?

1st graft.

4

which immune cell is responsible for rejection?

T-cell

5

T-cells recognize what?

MHC I : universally expressed (CD8)
MHC II : APC inducible (CD4)

6

MHC genes are static?

Nope. highly polymorphic

7

HLA matching of how many usually?

6

8

Renal vs. Lung transplant which one has more HLA mismatches?

Lung because of time and shorter waiting list

9

3 types of rejection are?

antibody mediated: immediate
acute: days-weeks: T-cells
Chronic: months-years: Ab? immune complexes? viruses?

10

what helps to determine what preformed antibodies you have?

blood
MHC
blood transfusions
preg
transplant

11

what happens if you get early episodes of acute rejection?

more problem with chronic rejection in future

12

2 non-immunological causes of chronic rejection?

viruses, ischaemia-reperfusion injury

13

what happens histologically in chronic rejection?

scarring/fibrosis around tubules etc.

14

chronic allograft rejection what can happen in:
Kidney?
Liver?
Lung?

nephropathy
scarring of bile ducts
bronchiolitis obliterans syndrome

15

hyperacute rejection mediated by?

antibodies and complement

16

3 ways to prevent rejection?

match ABO
match MHC/HLA
immunosuppresive drugs

17

oldes immunosuppressive drug?

azathioprine

18

what drug is good at taking out recently activated T-cells?

cyclosporin

19

cyclosporin and tacrolimus inhibits what?

calcineurin

20

what do calcineurin inhibitors leave you vulnerable to?

viruses

21

steroids for anti-rejection for what?

decrease lymphocytes and reaction to antigens but more risk of infection

22

what does azathioprine do?

non-specifically inhibits DNA and RNA synthesis, blocks IL2 prod

23

do we just use one drug for immunosuppression ? why?

use cocktail, so what you can use lower doses of the individual drugs and minimize side effects

24

organ regen involves?

decellularize a donor organ to get scaffolding, then populate with recipient cells to grow